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Nucleic Acids Research, 1976, Vol. 3, No. 9 2223-2232
© 1976

Articles

RNA chain elongation on a chromatin template

Adinah Solage and Howard Cedar

Department of Biochemistry, The Hebrew University-Hadassah Medical School Jerusalem, Israel

Received March 17, 1976. The rate of RNA chain elongation has been measured with DNA and chromatin as template. RNA propagation on chromatin is about 50% of the rate found with DNA. Kinetic experiments demonstrate that the inhibition is not due to interference with the addition of the nucleoside triphosphates. Analysis of the dependence of propagation on the Tm of DNA shows that the inhibition cannot be due to an effect on DNA unwinding. We conclude that chromatin proteins interfere with the translocation of the RNA polymerase along the DNA template.


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