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Nucleic Acids Research, 2002, Vol. 30, No. 1 149-151
© 2002 Oxford University Press

Homophila: human disease gene cognates in Drosophila

Samson Chien1,2, Lawrence T. Reiter2, Ethan Bier2 and Michael Gribskov1,2,*

1San Diego Supercomputer Center and 2Department of Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0349, USA

Although many human genes have been associated with genetic diseases, knowing which mutations result in disease phenotypes often does not explain the etiology of a specific disease. Drosophila melanogaster provides a powerful system in which to use genetic and molecular approaches to investigate human genetic diseases. Homophila is an intergenomic resource linking the human and fly genomes in order to stimulate functional genomic investigations in Drosophila that address questions about genetic disease in humans. Homophila provides a comprehensive linkage between the disease genes compiled in Online Mendelian Inheritance in Man (OMIM) and the complete Drosophila genomic sequence. Homophila is a relational database that allows searching based on human disease descriptions, OMIM number, human or fly gene names, and sequence similarity, and can be accessed at http://homophila.sdsc.edu.

* To whom correspondence should be addressed at: San Diego Supercomputer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0537, USA. Tel: +1 858 534 8312; Fax: +1 858 822 0873; Email: gribskov{at}sdsc.edu


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