Nucleic Acids Research, 2002, Vol. 30, No. 1 235-238
© 2002 Oxford University Press
The PROSITE database, its status in 2002
Swiss Institute of Bioinformatics (SIB), Swiss Institute for Experimental Cancer Research (ISREC), CH-1066 Epalinges /Lausanne, Switzerland, 1Swiss Institute of Bioinformatics (SIB), CMU, University of Geneva, 1 rue Michel Servet, CH-1211 Geneva 4, Switzerland and 2MEMOREC, Stoffel GmbH, Stoeckheimer Weg 1, D-50829 Koeln, Germany
PROSITE [Bairoch and Bucher (1994) Nucleic Acids Res., 22, 3583–3589; Hofmann et al. (1999) Nucleic Acids Res., 27, 215–219] is a method of identifying the functions of uncharacterized proteins translated from genomic or cDNA sequences. The PROSITE database (http://www.expasy.org/prosite/) consists of biologically significant patterns and profiles designed in such a way that with appropriate computational tools it can rapidly and reliably help to determine to which known family of proteins (if any) a new sequence belongs, or which known domain(s) it contains.
* To whom correspondence should be addressed. Tel: +41 21 692 5892; Fax: +41 21 692 5945; Email: philipp.bucher{at}isrec.unil.ch
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 A. S. Heimann, M. H. Favarato, F. C. Gozzo, V. Rioli, F. R. Carreno, M. N. Eberlin, E. S. Ferro, J. H. Krege, and J. E. Krieger ACE gene titration in mice uncovers a new mechanism for ACE on the control of body weight Physiol Genomics, January 20, 2005; 20(2): 173 - 182. [Abstract] [Full Text] [PDF]
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Y. Chen, Y. Zhang, Y. Yin, G. Gao, S. Li, Y. Jiang, X. Gu, and J. Luo SPD--a web-based secreted protein database Nucleic Acids Res., January 1, 2005; 33(suppl_1): D169 - D173. [Abstract] [Full Text] [PDF]
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Q. J. Su, L. Lu, S. Saxonov, and D. L. Brutlag eBLOCKs: enumerating conserved protein blocks to achieve maximal sensitivity and specificity Nucleic Acids Res., January 1, 2005; 33(suppl_1): D178 - D182. [Abstract] [Full Text] [PDF]
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D. Guo, K. Hu, Y. Lei, Y. Wang, T. Ma, and D. He Identification and Characterization of a Novel Cytoplasm Protein ICF45 That Is Involved in Cell Cycle Regulation J. Biol. Chem., December 17, 2004; 279(51): 53498 - 53505. [Abstract] [Full Text] [PDF]
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A. E. Whitfield, D. E. Ullman, and T. L. German Expression and Characterization of a Soluble Form of Tomato Spotted Wilt Virus Glycoprotein GN J. Virol., December 1, 2004; 78(23): 13197 - 13206. [Abstract] [Full Text] [PDF]
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 Y. Hitomi, N. Tsuchiya, A. Kawasaki, J. Ohashi, T. Suzuki, C. Kyogoku, T. Fukazawa, S. Bejrachandra, U. Siriboonrit, D. Chandanayingyong, et al. CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B Hum. Mol. Genet., December 1, 2004; 13(23): 2907 - 2917. [Abstract] [Full Text] [PDF]
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J. L. McMurry, J. S. Van Arnam, M. Kihara, and R. M. Macnab Analysis of the Cytoplasmic Domains of Salmonella FlhA and Interactions with Components of the Flagellar Export Machinery J. Bacteriol., November 15, 2004; 186(22): 7586 - 7592. [Abstract] [Full Text] [PDF]
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W. J. Song, Q. W. Qin, J. Qiu, C. H. Huang, F. Wang, and C. L. Hew Functional Genomics Analysis of Singapore Grouper Iridovirus: Complete Sequence Determination and Proteomic Analysis J. Virol., November 15, 2004; 78(22): 12576 - 12590. [Abstract] [Full Text] [PDF]
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F. C. Minion, E. J. Lefkowitz, M. L. Madsen, B. J. Cleary, S. M. Swartzell, and G. G. Mahairas The Genome Sequence of Mycoplasma hyopneumoniae Strain 232, the Agent of Swine Mycoplasmosis J. Bacteriol., November 1, 2004; 186(21): 7123 - 7133. [Abstract] [Full Text] [PDF]
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A. Teplyakov, G. Obmolova, E. Sarikaya, S. Pullalarevu, W. Krajewski, A. Galkin, A. J. Howard, O. Herzberg, and G. L. Gilliland Crystal Structure of the YgfZ Protein from Escherichia coli Suggests a Folate-Dependent Regulatory Role in One-Carbon Metabolism J. Bacteriol., November 1, 2004; 186(21): 7134 - 7140. [Abstract] [Full Text] [PDF]
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 J. A. Pighin, H. Zheng, L. J. Balakshin, I. P. Goodman, T. L. Western, R. Jetter, L. Kunst, and A. L. Samuels Plant Cuticular Lipid Export Requires an ABC Transporter Science, October 22, 2004; 306(5696): 702 - 704. [Abstract] [Full Text] [PDF]
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P. Malik and J. B. Clements Protein kinase CK2 phosphorylation regulates the interaction of Kaposi's sarcoma-associated herpesvirus regulatory protein ORF57 with its multifunctional partner hnRNP K Nucleic Acids Res., October 14, 2004; 32(18): 5553 - 5569. [Abstract] [Full Text] [PDF]
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I. Alam, A. Dress, M. Rehmsmeier, and G. Fuellen Comparative homology agreement search: An effective combination of homology-search methods PNAS, September 21, 2004; 101(38): 13814 - 13819. [Abstract] [Full Text] [PDF]
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J. A. Schmidt, G. F. Browning, and P. F. Markham Mycoplasma hyopneumoniae p65 Surface Lipoprotein Is a Lipolytic Enzyme with a Preference for Shorter-Chain Fatty Acids J. Bacteriol., September 1, 2004; 186(17): 5790 - 5798. [Abstract] [Full Text] [PDF]
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H. M. Kivela, R. Daugelavicius, R. H. Hankkio, J. K. H. Bamford, and D. H. Bamford Penetration of Membrane-Containing Double-Stranded-DNA Bacteriophage PM2 into Pseudoalteromonas Hosts J. Bacteriol., August 15, 2004; 186(16): 5342 - 5354. [Abstract] [Full Text] [PDF]
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 L. Gebbie, M. Benghezal, S. Cornillon, R. Froquet, N. Cherix, M. Malbouyres, Y. Lefkir, C. Grangeasse, S. Fache, J. Dalous, et al. Phg2, a Kinase Involved in Adhesion and Focal Site Modeling in Dictyostelium Mol. Biol. Cell, August 1, 2004; 15(8): 3915 - 3925. [Abstract] [Full Text] [PDF]
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J. N. Bragg, D. M. Lawrence, and A. O. Jackson The N-Terminal 85 Amino Acids of the Barley Stripe Mosaic Virus {gamma}b Pathogenesis Protein Contain Three Zinc-Binding Motifs J. Virol., July 15, 2004; 78(14): 7379 - 7391. [Abstract] [Full Text] [PDF]
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I. Niedick, N. Froese, A. Oumard, P. P. Mueller, M. Nourbakhsh, H. Hauser, and M. Koster Nucleolar localization and mobility analysis of the NF-{kappa}B repressing factor NRF J. Cell Sci., July 15, 2004; 117(16): 3447 - 3458. [Abstract] [Full Text] [PDF]
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J. M. Cliff, I. N. J. Andrade, R. Mistry, C. L. Clayton, M. G. Lennon, A. P. Lewis, K. Duncan, P. T. Lukey, and H. M. Dockrell Differential Gene Expression Identifies Novel Markers of CD4+ and CD8+ T Cell Activation Following Stimulation by Mycobacterium tuberculosis J. Immunol., July 1, 2004; 173(1): 485 - 493. [Abstract] [Full Text] [PDF]
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P. K. Papasaikas, P. G. Bagos, Z. I. Litou, V. J. Promponas, and S. J. Hamodrakas PRED-GPCR: GPCR recognition and family classification server Nucleic Acids Res., July 1, 2004; 32(suppl_2): W380 - W382. [Abstract] [Full Text] [PDF]
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