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Nucleic Acids Research, 2002, Vol. 30, No. 1 239-241
© 2002 Oxford University Press

PRINTS and PRINTS-S shed light on protein ancestry

T. K. Attwood1,2,*, M. J. Blythe3, D. R. Flower3, A. Gaulton1, J. E. Mabey1, N. Maudling1, L. McGregor4, A. L. Mitchell1,2, G. Moulton1, K. Paine3 and P. Scordis1

1School of Biological Sciences, The University of Manchester, Manchester M13 9PT, UK, 2EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, 3Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, UK and 4INSERM Unit 331, Faculty of Medicine R.T.H. Laënnec, Rue G. Paradin, 69372 Lyon cedex 08, France

The PRINTS database houses a collection of protein fingerprints. These may be used to make family and tentative functional assignments for uncharacterised sequences. The September 2001 release (version 32.0) includes 1600 fingerprints, encoding ~10 000 motifs, covering a range of globular and membrane proteins, modular polypeptides and so on. In addition to its continued steady growth, we report here its use as a source of annotation in the InterPro resource, and the use of its relational cousin, PRINTS-S, to model relationships between families, including those beyond the reach of conventional sequence analysis approaches. The database is accessible for BLAST, fingerprint and text searches at http://www.bioinf.man.ac.uk/dbbrowser/PRINTS/.

* To whom correspondence should be addressed at: School of Biological Sciences, The University of Manchester, Manchester M13 9PT, UK. Tel: +44 161 275 5766; Fax: +44 161 275 5082; Email: attwood{at}bioinf.man.ac.uk


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