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Nucleic Acids Research, 2002, Vol. 30, No. 1 364-368
© 2002 Oxford University Press

NUREBASE: database of nuclear hormone receptors

Jorge Duarte, Guy Perrière1, Vincent Laudet and Marc Robinson-Rechavi*

Laboratoire de Biologie Moléculaire et Cellulaire, CNRS UMR 5665, École Normale Supérieure de Lyon, 46 allée d’Italie, 69364 Lyon Cedex 07, France and 1Laboratoire de Biométrie et Biologie Évolutive, CNRS UMR 5558, Université Claude Bernard, Lyon 1, 43 boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France

Nuclear hormone receptors are an abundant class of ligand activated transcriptional regulators, found in varying numbers in all animals. Based on our experience of managing the official nomenclature of nuclear receptors, we have developed NUREBASE, a database containing protein and DNA sequences, reviewed protein alignments and phylogenies, taxonomy and annotations for all nuclear receptors. The reviewed NUREBASE is completed by NUREBASE_DAILY, automatically updated every 24 h. Both databases are organized under a client/server architecture, with a client written in Java which runs on any platform. This client, named FamFetch, integrates a graphical interface allowing selection of families, and manipulation of phylogenies and alignments. NUREBASE sequence data is also accessible through a World Wide Web server, allowing complex queries. All information on accessing and installing NUREBASE may be found at http://www.ens-lyon.fr/LBMC/laudet/nurebase.html.

* To whom correspondance should be addressed. Tel: +33 472 72 86 85; Fax: +33 472 72 80 80; Email: marc.robinson{at}ens-lyon.fr


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