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Nucleic Acids Research, 2002, Vol. 30, No. 1 379-382
© 2002 Oxford University Press

MDB: the Metalloprotein Database and Browser at The Scripps Research Institute

Jesus M. Castagnetto, Sean W. Hennessy, Victoria A. Roberts, Elizabeth D. Getzoff, John A. Tainer and Michael E. Pique*

The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA

The Metalloprotein Database and Browser (MDB; http://metallo.scripps.edu) at The Scripps Research Institute is a web-accessible resource for metalloprotein research. It offers the scientific community quantitative information on geometrical parameters of metal-binding sites in protein structures available from the Protein Data Bank (PDB). The MDB also offers analytical tools for the examination of trends or patterns in the indexed metal-binding sites. A user can perform interactive searches, metal-site structure visualization (via a Java applet), and analysis of the quantitative data by accessing the MDB through a web browser without requiring an external application or platform-dependent plugin. The MDB also has a non-interactive interface with which other web sites and network-aware applications can seamlessly incorporate data or statistical analysis results from metal-binding sites. The information contained in the MDB is periodically updated with automated algorithms that find and index metal sites from new protein structures released by the PDB.

* To whom correspondence should be addressed. Tel: +1 858 784 9775; Fax: +1 878 784 2860; Email: mp{at}scripps.edu


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