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Nucleic Acids Research, 2002, Vol. 30, No. 1 405-408
© 2002 Oxford University Press

SWEET-DB: an attempt to create annotated data collections for carbohydrates

Alexander Loß, Peter Bunsmann, Andreas Bohne1, Annika Loß, Eberhard Schwarzer, Elke Lang2 and Claus-W. von der Lieth1,*

University Hildesheim, Institute of Physics and Technical Informatics, Marienburger Platz 22, 31141 Hildesheim, Germany, 1German Cancer Research Center, Spectroscopic Department, Im Neuenheimer Feld 240, 69120 Heidelberg, Germany and 2University of Applied Sciences Darmstadt, Department for Information and Knowledge Management, Schöfferstraße 1-3, D-64295 Darmstadt, Germany

Complex carbohydrates are known as mediators of complex cellular events. Concerning their structural diversity, their potential of information content is several orders of magnitude higher in a short sequence than any other biological macromolecule. SWEET-DB (http://www.dkfz.de/spec2/sweetdb/) is an attempt to use modern web techniques to annotate and/or cross-reference carbohydrate-related data collections which allow glycoscientists to find important data for compounds of interest in a compact and well-structured representation. Currently, reference data taken from three data sources can be retrieved for a given carbohydrate (sub)structure. The sources are CarbBank structures and literature references (linked to NCBI PubMed service), NMR data taken from SugaBase and 3D co-ordinates generated with SWEET-II. The main purpose of SWEET-DB is to enable an easy access to all data stored for one carbohydrate structure entering a complete sequence or parts thereof. Access to SWEET-DB contents is provided with the help of separate input spreadsheets for (sub)structures, bibliographic data, general structural data like molecular weight, NMR spectra and biological data. A detailed online tutorial is available at http://www.dkfz.de/spec2/sweetdb/nar/.

* To whom correspondence should be addressed. Tel: +49 6221 42 4541; Fax: +49 6221 42 4554; Email: w.vonderlieth{at}dkfz.de Present addresses: Alexander Loß and Annika Loß, Gebrüder Gerstenberg GmbH & Co, 31134 Hildesheim, Germany Peter Bunsmann, Bosch-Blaupunkt, 31134 Hildesheim, Germany


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