Nucleic Acids Research, 2002, Vol. 30, No. 11 2453-2459
© 2002 Oxford University Press
A novel type of conserved DNA-binding domain in the transcriptional regulators of the AlgR/AgrA/LytR family
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Sequence analysis of bacterial genomes revealed a novel DNA-binding domain. This domain is found in several response regulators of the two-component signal transduction system, such as Pseudomonas aeruginosa AlgR, involved in the regulation of alginate biosynthesis and in the pathogenesis of cystic fibrosis; Clostridium perfringens VirR, a regulator of virulence factors, and in several regulators of bacteriocin biosynthesis, previously unified in the AgrA/ComE family. Most of the transcriptional regulators that contain this DNA-binding domain are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. We refer to it as the LytTR (‘litter’) domain, after Bacillus subtilis LytT and Staphylococcus aureus LytR response regulators, involved in regulation of cell autolysis. In addition to response regulators, the LytTR domain is found in combination with MHYT, PAS and other sensor domains.
* To whom correspondence should be addressed. Tel: +1 301 435 5910; Fax: +1 301 435 7794; Email: galperin{at}ncbi.nlm.nih.gov
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  W. L. Cody, C. L. Pritchett, A. K. Jones, A. J. Carterson, D. Jackson, A. Frisk, M. C. Wolfgang, and M. J. Schurr Pseudomonas aeruginosa AlgR Controls Cyanide Production in an AlgZ-Dependent Manner J. Bacteriol., May 1, 2009; 191(9): 2993 - 3002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Fujii, C. Ingham, J. Nakayama, M. Beerthuyzen, R. Kunuki, D. Molenaar, M. Sturme, E. Vaughan, M. Kleerebezem, and W. de Vos Two Homologous Agr-Like Quorum-Sensing Systems Cooperatively Control Adherence, Cell Morphology, and Cell Viability Properties in Lactobacillus plantarum WCFS1 J. Bacteriol., December 1, 2008; 190(23): 7655 - 7665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Frederick, E. A. Rogers, and R. T. Marconi Analysis of a Growth-Phase-Regulated Two-Component Regulatory System in the Periodontal Pathogen Treponema denticola J. Bacteriol., September 15, 2008; 190(18): 6162 - 6169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Kowalko and M. E. Sebert The Streptococcus pneumoniae Competence Regulatory System Influences Respiratory Tract Colonization Infect. Immun., July 1, 2008; 76(7): 3131 - 3140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Kerby, H. Youn, and G. P. Roberts RcoM: A New Single-Component Transcriptional Regulator of CO Metabolism in Bacteria J. Bacteriol., May 1, 2008; 190(9): 3336 - 3343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Belete, H. Lu, and D. J. Wozniak Pseudomonas aeruginosa AlgR Regulates Type IV Pilus Biosynthesis by Activating Transcription of the fimU-pilVWXY1Y2E Operon J. Bacteriol., March 15, 2008; 190(6): 2023 - 2030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Leech, A. Sprinkle, L. Wood, D. J. Wozniak, and D. E. Ohman The NtrC Family Regulator AlgB, Which Controls Alginate Biosynthesis in Mucoid Pseudomonas aeruginosa, Binds Directly to the algD Promoter J. Bacteriol., January 15, 2008; 190(2): 581 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Ciofu, B. Lee, M. Johannesson, N. O. Hermansen, P. Meyer, N. Hoiby, and the Scandinavian Cystic Fibrosis Study Consortium Investigation of the algT operon sequence in mucoid and non-mucoid Pseudomonas aeruginosa isolates from 115 Scandinavian patients with cystic fibrosis and in 88 in vitro non-mucoid revertants Microbiology, January 1, 2008; 154(1): 103 - 113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. J. Sturme, C. Francke, R. J. Siezen, W. M. de Vos, and M. Kleerebezem Making sense of quorum sensing in lactobacilli: a special focus on Lactobacillus plantarum WCFS1 Microbiology, December 1, 2007; 153(12): 3939 - 3947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. P. Carter, D. Lyras, D. L. Allen, K. E. Mackin, P. M. Howarth, J. R. O'Connor, and J. I. Rood Binary Toxin Production in Clostridium difficile Is Regulated by CdtR, a LytTR Family Response Regulator J. Bacteriol., October 15, 2007; 189(20): 7290 - 7301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kreth, D. C. I. Hung, J. Merritt, J. Perry, L. Zhu, S. D. Goodman, D. G. Cvitkovitch, W. Shi, and F. Qi The response regulator ComE in Streptococcus mutans functions both as a transcription activator of mutacin production and repressor of CSP biosynthesis Microbiology, June 1, 2007; 153(6): 1799 - 1807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ogura, K. Tsukahara, K. Hayashi, and T. Tanaka The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion Microbiology, March 1, 2007; 153(3): 667 - 675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Y. Galperin Structural classification of bacterial response regulators: diversity of output domains and domain combinations. J. Bacteriol., June 1, 2006; 188(12): 4169 - 4182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tapparel, A. Monod, and W. L. Kelley The DNA-binding domain of the Escherichia coli CpxR two-component response regulator is constitutively active and cannot be fully attenuated by fused adjacent heterologous regulatory domains Microbiology, February 1, 2006; 152(2): 431 - 441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Azcarate-Peril, O. McAuliffe, E. Altermann, S. Lick, W. M. Russell, and T. R. Klaenhammer Microarray Analysis of a Two-Component Regulatory System Involved in Acid Resistance and Proteolytic Activity in Lactobacillus acidophilus Appl. Envir. Microbiol., October 1, 2005; 71(10): 5794 - 5804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Dal Bello, J. Walter, S. Roos, H. Jonsson, and C. Hertel Inducible Gene Expression in Lactobacillus reuteri LTH5531 during Type II Sourdough Fermentation Appl. Envir. Microbiol., October 1, 2005; 71(10): 5873 - 5878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. van der Ploeg Regulation of Bacteriocin Production in Streptococcus mutans by the Quorum-Sensing System Required for Development of Genetic Competence J. Bacteriol., June 15, 2005; 187(12): 3980 - 3989. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Altermann, W. M. Russell, M. A. Azcarate-Peril, R. Barrangou, B. L. Buck, O. McAuliffe, N. Souther, A. Dobson, T. Duong, M. Callanan, et al. Inaugural Article: From the Cover: Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM PNAS, March 15, 2005; 102(11): 3906 - 3912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Koenig, J. L. Ray, S. J. Maleki, M. S. Smeltzer, and B. K. Hurlburt Staphylococcus aureus AgrA Binding to the RNAIII-agr Regulatory Region J. Bacteriol., November 15, 2004; 186(22): 7549 - 7555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Lizewski, J. R. Schurr, D. W. Jackson, A. Frisk, A. J. Carterson, and M. J. Schurr Identification of AlgR-Regulated Genes in Pseudomonas aeruginosa by Use of Microarray Analysis J. Bacteriol., September 1, 2004; 186(17): 5672 - 5684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Penaloza-Vazquez, M. K. Fakhr, A. M. Bailey, and C. L. Bender AlgR functions in algC expression and virulence in Pseudomonas syringae pv. syringae Microbiology, August 1, 2004; 150(8): 2727 - 2737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. McGowan, J. R. O'Connor, J. K. Cheung, and J. I. Rood The SKHR Motif Is Required for Biological Function of the VirR Response Regulator from Clostridium perfringens J. Bacteriol., October 15, 2003; 185(20): 6205 - 6208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Chhabra, K. R. Shockley, S. B. Conners, K. L. Scott, R. D. Wolfinger, and R. M. Kelly Carbohydrate-induced Differential Gene Expression Patterns in the Hyperthermophilic Bacterium Thermotoga maritima J. Biol. Chem., February 21, 2003; 278(9): 7540 - 7552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Hancock and M. Perego Two-Component Signal Transduction in Enterococcus faecalis J. Bacteriol., November 1, 2002; 184(21): 5819 - 5825. [Full Text] [PDF]
|
|