Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow Print PDF (285K) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (7)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Benecke, A.
Right arrow Articles by Losson, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Benecke, A.
Right arrow Articles by Losson, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 2002, Vol. 30, No. 11 2508-2514
© 2002 Oxford University Press

ADA3-containing complexes associate with estrogen receptor alpha

Arndt Benecke, Claudine Gaudon, Jean-Marie Garnier, Elmar vom Baur, Pierre Chambon* and Régine Losson

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, BP163, 67404 Illkirch Cedex, France

Transcriptional repression and activation by nuclear receptors (NRs) are brought about by coregulator complexes. These complexes modify the chromatin environment of target genes and affect the activity of the basal transcription machinery. We have previously implicated the yeast ADA3 protein in transcriptional activation by estrogen and retinoid X receptors in yeast and mammalian cells. Here we report the cloning of the mouse homolog of ADA3 and its characterization with respect to the estrogen receptor alpha (ER{alpha}) function. Mouse mADA3 is 23% identical and 47% similar to yeast yADA3, and mADA3 in contrast to yADA3 does not interact with NRs directly even though it contains two LxxLL NR boxes. However, the ADA3-containing TBP-free-TAF-containing complex (TFTC) can interact with ER{alpha} in a ligand-independent manner, indicating that other subunits of the complex are sufficient to mediate interaction with NRs.

* To whom correspondence should be addressed. Tel: +33 3 88 65 32 13; Fax: +33 3 88 65 32 03; Email: chambon{at}igbmc.u-strasbg.fr Present address:Arndt Benecke, INSERM U417, Hôpital St Antoine, 75571 Paris Cedex 12, France


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
B. Grau, C. Popescu, L. Torroja, D. Ortuno-Sahagun, I. Boros, and A. Ferrus
Transcriptional Adaptor ADA3 of Drosophila melanogaster Is Required for Histone Modification, Position Effect Variegation, and Transcription
Mol. Cell. Biol., January 1, 2008; 28(1): 376 - 385.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Meng, Y. Zhao, A. Nag, M. Zeng, G. Dimri, Q. Gao, D. E. Wazer, R. Kumar, H. Band, and V. Band
Human ADA3 Binds to Estrogen Receptor (ER) and Functions As a Coactivator for ER-mediated Transactivation
J. Biol. Chem., December 24, 2004; 279(52): 54230 - 54240.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Akiyama, N. Fujisawa, Y. Tashiro, N. Takanabe, A. Sugiyama, and F. Tashiro
The Role of Transcriptional Corepressor Nif3l1 in Early Stage of Neural Differentiation via Cooperation with Trip15/CSN2
J. Biol. Chem., March 14, 2003; 278(12): 10752 - 10762.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Zeng, A. Kumar, G. Meng, Q. Gao, G. Dimri, D. Wazer, H. Band, and V. Band
Human Papilloma Virus 16 E6 Oncoprotein Inhibits Retinoic X Receptor-mediated Transactivation by Targeting Human ADA3 Coactivator
J. Biol. Chem., November 15, 2002; 277(47): 45611 - 45618.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.