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Nucleic Acids Research, 2002, Vol. 30, No. 13 2899-2905
© 2002 Oxford University Press

The chAB4 and NF1-related long-range multisequence DNA families are contiguous in the centromeric heterochromatin of several human chromosomes

Imre Cserpán*, Róbert Katona, Tünde Praznovszky, Edit Novák, Márta Rózsavölgyi, Erika Csonka, Mónika Mórocz, Katalin Fodor and Gyula Hadlaczky

Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Temesvári krt. 62, H-6701 Szeged, P.O.B. 521, Hungary

We have investigated the large-scale organization of the human chAB4-related long-range multisequence family, a low copy-number repetitive DNA located in the pericentromeric heterochromatin of several human chromosomes. Analysis of genomic clones revealed large-scale (~100 kb or more) sequence conservation in the region flanking the prototype chAB4 element. We demonstrated that this low copy-number family is connected to another long-range repeat, the NF1-related ({Psi}NF1) multisequence. The two DNA types are joined by an ~2 kb-long tandem repeat of a 48-bp satellite. Although the chAB4- and NF1-like sequences were known to have essentially the same chromosomal localization, their close association is reported here for the first time. It indicates that they are not two independent long-range DNA families, but are parts of a single element spanning ~200 kb or more. This view is consistent both with their similar chromosomal localizations and the high levels of sequence conservation among copies found on different chromosomes. We suggest that the master copy of the linked chAB4–{Psi}NF1 DNA segment appeared first on the ancestor of human chromosome 17.

* To whom correspondence should be addressed. Tel: +36 62 432 080; Fax: +36 62 433 397; Email: cserpani{at}nucleus.szbk.u-szeged.hu+AF401203, AF402806, AF402807


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