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Nucleic Acids Research, 2002, Vol. 30, No. 14 3245-3252
© 2002 Oxford University Press

SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex

Rongjia Zhou, Nathalie Bonneaud1, Chao-Xing Yuan2, Pascal de Santa Barbara1, Brigitte Boizet1, Schomber Tibor3, Gerd Scherer3, Robert G. Roeder2, Francis Poulat and Philippe Berta*,1

Department of Genetics, College of Life Sciences, Wuhan University, Wuhan 430072, People’s Republic of China, 1 Human Molecular Genetics Group, Institut de Génétique Humaine, UPR1142 CNRS, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France, 2 Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA and 3 Institute of Human Genetics, University of Freiburg, D-79106 Freiburg, Germany

*To whom correspondence should be addressed. Tel: +33 4 99 61 99 55; Fax: +33 4 99 61 99 42; Email: berta{at}igh.cnrs.fr
The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors

SOX9 transcription factor is involved in chondrocyte differentiation and male sex determination. Heterozygous defects in the human SOX9 gene cause campomelic dysplasia. The mechanisms behind SOX9 function are not understood despite the description of different target genes. This study therefore sets out to identify SOX9-associated proteins to unravel how SOX9 interacts with the cellular transcription machinery. We report the ability of SOX9 to interact with TRAP230, a component of the thyroid hormone receptor-associated protein (TRAP) complex. Both in vitro and in vivo assays have confirmed that the detected interaction is specific and occurs endogenously in cells. Using co-transfection experiments, we have also shown that the TRAP230 interacting domain can act in a dominant-negative manner regarding SOX9 activity. Our results add SOX9 to the list of activators that communicate with the general transcription machinery through the TRAP complex and suggest a basis for the collaboration of SOX9 with different coactivators that could contact the same coactivator/integrator complex.


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