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Nucleic Acids Research, 2002, Vol. 30, No. 4 839-865
© 2002 Oxford University Press

Survey and Summary

Natural and pharmacological regulation of telomerase

Jean-Louis Mergny*, Jean-François Riou1, Patrick Mailliet2, Marie-Paule Teulade-Fichou3 and Eric Gilson4

Laboratoire de Biophysique, Muséum National d’Histoire Naturelle, INSERM U 201, CNRS UMR 8646, 43 rue Cuvier, F-75005 Paris, France, 1Unité MéDIAN, CNRS FRE 2141, UFR de Pharmacie, Université de Reims Champagne-Ardenne, 51 rue Cognacq-Jay, F-51096 Reims Cedex, France, 2Aventis-Pharma SA, Centre de Recherche de Vitry-Alfortville, Quai Jules Guesde, F-94805 Vitry/Seine, France, 3Laboratoire de Chimie des Interactions Moléculaires, Collège de France, CNRS UPR 285, 11 place Marcelin Berthelot, F-75005 Paris, France and 4Laboratoire de Biologie Moléculaire et Cellulaire, CNRS UMR 5665, Ecole Normale Supérieure de Lyon, 46 allée d’Italie, F-69364 Lyon, France

The extremities of eukaryotic chromosomes are called telomeres. They have a structure unlike the bulk of the chromosome, which allows the cell DNA repair machinery to distinguish them from ‘broken’ DNA ends. But these specialised structures present a problem when it comes to replicating the DNA. Indeed, telomeric DNA progressively erodes with each round of cell division in cells that do not express telomerase, a specialised reverse transcriptase necessary to fully duplicate the telomeric DNA. Telomerase is expressed in tumour cells but not in most somatic cells and thus telomeres and telomerase may be proposed as attractive targets for the discovery of new anticancer agents.

* To whom correspondence should be addressed. Tel: +33 1 40 79 36 89; Fax: +33 1 40 79 37 05; Email: mergny{at}vnumail.com


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