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Nucleic Acids Research, 2002, Vol. 30, No. 7 1558-1562
© 2002 Oxford University Press

Multiple thiol-anchor capped DNA–gold nanoparticle conjugates

Zhi Li, Rongchao Jin, Chad A. Mirkin* and Robert L. Letsinger

Northwestern University, Department of Chemistry and Institute for Nanotechnology, 2145 Sheridan Road, Evanston, IL 60208, USA

We report the synthesis of a novel trithiol-capped oligodeoxyribonucleotide and gold nanoparticle conjugates prepared from it. These DNA–gold nanoparticle conjugates exhibit substantially higher stability than analogs prepared from monothiol and cyclic disulfide-capped oligodeoxyribonucleotides, but comparable hybridization properties. A quantitative analysis of their stability under a range of conditions is provided. Significantly, this novel trithiol oligodeoxyribonucleotide can be used to stabilize particles >30 nm in diameter, which are essential for many diagnostic applications.

* To whom correspondence should be addressed. Tel: +1 847 491 2907; Fax: +1 847 467 5123; Email: camirkin{at}chem.northwestern.edu Correspondence may also be addressed to Robert L. Letsinger. Tel: +1 847 491 7674; Fax: +1 847 491 7713; Email: r-letsinger{at}chem.northwestern.edu


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