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Nucleic Acids Research, 2003, Vol. 31, No. 1 328-330
© 2003 Oxford University Press

The Nuclear Protein Database (NPD): sub-nuclear localisation and functional annotation of the nuclear proteome

G. Dellaire1,2, R. Farrall1 and W.A. Bickmore*,1

1 MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK 2 The Hospital for Sick Children, Program in Cell Biology, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada

*To whom correspondence should be addressed. Fax: +44 131 343 2620; Email: wendy.bickmore{at}hgu.mrc.ac.uk

ABSTRACT

The Nuclear Protein Database (NPD) is a curated database that contains information on more than 1300 vertebrate proteins that are thought, or are known, to localise to the cell nucleus. Each entry is annotated with information on predicted protein size and isoelectric point, as well as any repeats, motifs or domains within the protein sequence. In addition, information on the sub-nuclear localisation of each protein is provided and the biological and molecular functions are described using Gene Ontology (GO) terms. The database is searchable by keyword, protein name, sub-nuclear compartment and protein domain/motif. Links to other databases are provided (e.g. Entrez, SWISS-PROT, OMIM, PubMed, PubMed Central). Thus, NPD provides a gateway through which the nuclear proteome may be explored. The database can be accessed at http://npd.hgu.mrc.ac.uk and is updated monthly.


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