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Nucleic Acids Research, 2003, Vol. 31, No. 1 414-417
© 2003 Oxford University Press

The Proteome Analysis database: a tool for the in silico analysis of whole proteomes

Manuela Pruess*, Wolfgang Fleischmann, Alexander Kanapin, Youla Karavidopoulou, Paul Kersey, Evgenia Kriventseva, Virginie Mittard, Nicola Mulder, Isabelle Phan1, Florence Servant and Rolf Apweiler

EMBL Outstation, The European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK 1 Swiss Institute of Bioinformatics (SIB), CMU, Rue Michel-Servet 1, 1211 Geneve 4, Switzerland

*To whom correspondence should be addressed. Tel: +44 1223 4944327; Fax: +44 1223 494468; Email: mpr{at}ebi.ac.uk

ABSTRACT

The Proteome Analysis database (http://www.ebi.ac.uk/proteome/) has been developed by the Sequence Database Group at EBI utilizing existing resources and providing comparative analysis of the predicted protein coding sequences of the complete genomes of bacteria, archeae and eukaryotes. Three main projects are used, InterPro, CluSTr and GO Slim, to give an overview on families, domains, sites, and functions of the proteins from each of the complete genomes. Complete proteome analysis is available for a total of 89 proteome sets. A specifically designed application enables InterPro proteome comparisons for any one proteome against any other one or more of the proteomes in the database.


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