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Nucleic Acids Research, 2003, Vol. 31, No. 1 78-81
© 2003 Oxford University Press

MTID: a database of Sleeping Beauty transposon insertions in mice

Kevin Roberg-Perez*,1,2, Corey M. Carlson3 and David A. Largaespada1,3

1 University of Minnesota Cancer Center, Minneapolis, MN 55455, USA 2 UMCC Informatics Core, University of Minnesota, Minneapolis, MN 55455, USA 3 The Arnold and Mabel Beckman Center for Transposon Research, Department of Genetics, Cell Biology and Development, Minneapolis, MN 55455, USA

*To whom correspondence should be addressed. Email: rober144{at}umn.edu

ABSTRACT

The Sleeping Beauty (SB) transposon system provides the first random insertional mutagen available for germline genetic screens in mice. In preparation for a large scale project to create, map and manage up to 5000 SB insertions, we have developed the Mouse Transposon Insertion Database (MTID; http://mouse.ccgb.umn.edu/transposon/). Each insertion's genomic position, as well as the distance between the insertion and the nearest annotated gene, are determined by a sequence analysis pipeline. Users can search the database using a specified nucleotide or genetic map position to identify the nearest insertion. Mouse reports describe insertions carried, strain, genotype and dates of birth and death. Insertion reports describes chromosome, nucleotide and genetic map positions, as well as nearest gene data from Ensembl, NCBI and Celera. The flanking sequence used to map the insertion is also provided. Researchers will be able to identify insertions of interest and request mice or frozen sperm that carry the insertion.


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C. M. Carlson, A. J. Dupuy, S. Fritz, K. J. Roberg-Perez, C. F. Fletcher, and D. A. Largaespada
Transposon Mutagenesis of the Mouse Germline
Genetics, September 1, 2003; 165(1): 243 - 256.
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