Nucleic Acids Research, 2003, Vol. 31, No. 13 3406-3415
© 2003 Oxford University Press
Mfold web server for nucleic acid folding and hybridization prediction
Department of Mathematical Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
*Tel: +1 5182766902; Fax: +1 5182764824; Email: zukerm{at}rpi.edu
The abbreviated name, ‘mfold web server’, describes a number of closely related software applications available on the World Wide Web (WWW) for the prediction of the secondary structure of single stranded nucleic acids. The objective of this web server is to provide easy access to RNA and DNA folding and hybridization software to the scientific community at large. By making use of universally available web GUIs (Graphical User Interfaces), the server circumvents the problem of portability of this software. Detailed output, in the form of structure plots with or without reliability information, single strand frequency plots and ‘energy dot plots’, are available for the folding of single sequences. A variety of ‘bulk’ servers give less information, but in a shorter time and for up to hundreds of sequences at once. The portal for the mfold web server is http://www.bioinfo.rpi.edu/applications/mfold. This URL will be referred to as ‘MFOLDROOT’.
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R. Guo, W. Lin, J. Zhang, A. E. Simon, and D. B. Kushner Structural Plasticity and Rapid Evolution in a Viral RNA Revealed by In Vivo Genetic Selection J. Virol., January 15, 2009; 83(2): 927 - 939. [Abstract] [Full Text] [PDF]
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R. Yi, H. A. Pasolli, M. Landthaler, M. Hafner, T. Ojo, R. Sheridan, C. Sander, D. O'Carroll, M. Stoffel, T. Tuschl, et al. DGCR8-dependent microRNA biogenesis is essential for skin development PNAS, January 13, 2009; 106(2): 498 - 502. [Abstract] [Full Text] [PDF]
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 S. C. Pulvermacher, L. T. Stauffer, and G. V. Stauffer Role of the sRNA GcvB in regulation of cycA in Escherichia coli Microbiology, January 1, 2009; 155(1): 106 - 114. [Abstract] [Full Text] [PDF]
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S. C. Pulvermacher, L. T. Stauffer, and G. V. Stauffer Role of the Escherichia coli Hfq protein in GcvB regulation of oppA and dppA mRNAs Microbiology, January 1, 2009; 155(1): 115 - 123. [Abstract] [Full Text] [PDF]
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S. Malhotra-Kumar, A. Mazzariol, L. Van Heirstraeten, C. Lammens, P. de Rijk, G. Cornaglia, and H. Goossens Unusual resistance patterns in macrolide-resistant Streptococcus pyogenes harbouring erm(A) J. Antimicrob. Chemother., January 1, 2009; 63(1): 42 - 46. [Abstract] [Full Text] [PDF]
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A. P. McGraw, A. Mokdad, F. Major, P. C. Bevilacqua, and P. Babitzke Molecular basis of TRAP-5'SL RNA interaction in the Bacillus subtilis trp operon transcription attenuation mechanism RNA, January 1, 2009; 15(1): 55 - 66. [Abstract] [Full Text] [PDF]
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