Nucleic Acids Research, 2003, Vol. 31, No. 13 3503-3506
© 2003 Oxford University Press
Tcoffee@igs: a web server for computing, evaluating and combining multiple sequence alignments
Information Genomique et Structurale, CNRS, 31 Chemin Joseph Aiguier, 13 402 Marseille Cedex 20, France 1 High Performance Technical Computing Division, Hewlet Packard, BallyBrit, Galway, Ireland
*To whom correspondence should be addressed. Tel: +33 4 91 16 4606; Fax: +33 4 91 16 4549; Email: cedric.notredame{at}europe.com
This paper presents Tcoffee@igs, a new server provided to the community by Hewlet Packard computers and the Centre National de la Recherche Scientifique. This server is a web-based tool dedicated to the computation, the evaluation and the combination of multiple sequence alignments. It uses the latest version of the T-Coffee package. Given a set of unaligned sequences, the server returns an evaluated multiple sequence alignment and the associated phylogenetic tree. This server also makes it possible to evaluate the local reliability of an existing alignment and to combine several alternative multiple alignments into a single new one. Tcoffee@igs can be used for aligning protein, RNA or DNA sequences. Datasets of up to 100 sequences (2000 residues long) can be processed. The server and its documentation are available from: http://igs-server.cnrs-mrs.fr/Tcoffee/.
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