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Nucleic Acids Research, 2003, Vol. 31, No. 13 3824-3828
© 2003 Oxford University Press

Comprehensive quantitative analyses of the effects of promoter sequence elements on mRNA transcription

Michal Lapidot and Yitzhak Pilpel*

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel

*To whom correspondence should be addressed. Tel: +972 8 9346058; Fax: +972 8 9344108; Email; pilpel{at}weizmann.ac.ilv

We have generated a WWW interface for automated comprehensive analyses of promoter regulatory motifs and the effect they exert on mRNA expression profiles. The server provides a wide spectrum of analysis tools that allow de novo discovery of regulatory motifs, along with refinement and in-depth investigation of fully or partially characterized motifs. The presented discovery and analysis tools are fundamentally different from existing tools in their basic rational, statistical background and specificity and sensitivity towards true regulatory elements. We thus anticipate that the service will be of great importance to the experimental and computational biology communities alike. The motif discovery and diagnosis workbench is available at http://longitude.weizmann.ac.il/rMotif/.


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