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Nucleic Acids Research, 2003, Vol. 31, No. 3 799-804
© 2003 Oxford University Press

The pre-ribosomal network

Philipp Milkereit, Holger Kühn1, Nicole Gas and Herbert Tschochner*,1

Laboratoire de Biologie Moleculaire Eucaryote, F-32062 Toulouse, France and 1 Biochemie-Zentrum Heidelberg, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany

*To whom correspondence should be addressed. Tel: +49 6221 544149; Fax: +49 6221 544366; Email: im4{at}ix.urz.uni-heidelberg.de

Recent achievements in yeast functional proteomics have significantly advanced our knowledge about ribosome biogenesis. Here, we present a program developed to integrate data from various proteome analyses with cell biological data on components present in the ribosome producing factories. This program allows users to attribute factors to certain complexes and to specific steps of ribosome biogenesis. Thus, it helps to gain novel insights into the complex network involved in maturation of ribosomal subunits. The database can be accessed at the URL http://www.pre-ribosome.de.


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