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Nucleic Acids Research 2004 32(12):3651-3660; doi:10.1093/nar/gkh700
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Published online 9 July 2004

Nucleic Acids Research, Vol. 32 No. 12 © Oxford University Press 2004; all rights reserved

A set of BAC clones spanning the human genome

Martin Krzywinski, Ian Bosdet, Duane Smailus, Readman Chiu, Carrie Mathewson, Natasja Wye, Sarah Barber, Mabel Brown-John, Susanna Chan, Steve Chand, Alison Cloutier, Noreen Girn, Darlene Lee, Amara Masson, Michael Mayo, Teika Olson, Pawan Pandoh, Anna-Liisa Prabhu, Eric Schoenmakers2, Miranda Tsai, Donna Albertson3, Wan Lam1, Chik-On Choy4, Kazutoyo Osoegawa4, Shaying Zhao5, Pieter J. de Jong4, Jacqueline Schein, Steven Jones and Marco A. Marra*

BC Cancer Agency Genome Sciences Center and 1 BC Cancer Agency, Vancouver, BC V5Z 4E6, Canada, 2 Department of Human Genetics, 417, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands, 3 Cancer Research Institute, Box 0808, University of California at San Francisco, San Francisco, CA 94143-0808, USA, 4 BACPAC Resources, Children's Hospital Oakland, 747 52nd Street, Oakland, CA 94609, USA and 5 The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA

* To whom correspondence should be addressed. Tel: +1 604 877 6084; Fax: +1 604 877 6085; Email: mmarra{at}bcgsc.bc.ca

Received May 21, 2004; Revised and Accepted June 22, 2004

Using the human bacterial artificial chromosome (BAC) fingerprint-based physical map, genome sequence assembly and BAC end sequences, we have generated a fingerprint-validated set of 32 855 BAC clones spanning the human genome. The clone set provides coverage for at least 98% of the human fingerprint map, 99% of the current assembled sequence and has an effective resolving power of 79 kb. We have made the clone set publicly available, anticipating that it will generally facilitate FISH or array-CGH-based identification and characterization of chromosomal alterations relevant to disease.


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