Skip Navigation

Nucleic Acids Research 2004 32(19):e144; doi:10.1093/nar/gnh145
This Article
Right arrow Full Text Freely available
Right arrow Print PDF (421K) Freely available
Right arrow Supplementary Material
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Mao, Y.
Right arrow Articles by Yu, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mao, Y.
Right arrow Articles by Yu, D.
Related Collections
Right arrow Miscellaneous/other
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published online 26 October 2004

Nucleic Acids Research, Vol. 32 No. 19 © Oxford University Press 2004; all rights reserved

Reversibly switchable DNA nanocompartment on surfaces

Youdong Mao1,3, Chunxiong Luo1,3, Wei Deng6, Guangyin Jin2, Xiaomei Yu5, Zhaohui Zhang3, Qi Ouyang1,4,*, Runsheng Chen6 and Dapeng Yu2

1 Laboratory for Biotechnology, 2 Laboratory for Nanofabrication, 3 Department of Physics, 4 Center for Theoretical Biology and 5 Institute of Microelectronics, Peking University, Beijing 100871, China and 6 Laboratory for Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

* To whom correspondence should be addressed. Tel: +86 10 62756943; Fax: +86 10 62751615; Email: qi{at}pku.edu.cn
Correspondence may also be addressed to Youdong Mao. Tel: +86 10 62528034; Fax: +86 10 62751615; Email: jackmao{at}water.pku.edu.cn

Received July 27, 2004; Revised September 21, 2004; Accepted October 6, 2004

Biological macromolecules have been used to fabricate many nanostructures, biodevices and biomimetics because of their physical and chemical properties. But dynamic nanostructure and biomachinery that depend on collective behavior of biomolecules have not been demonstrated. Here, we report the design of DNA nanocompartments on surfaces that exhibit reversible changes in molecular mechanical properties. Such molecular nanocompartments are used to encage molecules, switched by the collective effect of Watson–Crick base-pairing interactions. This effect is used to perform molecular recognition. Furthermore, we found that ‘fuel’ strands with single-base variation cannot afford an efficient closing of nanocompartments, which allows highly sensitive label-free DNA array detection. Our results suggest that DNA nanocompartments can be used as building blocks for complex biomaterials because its core functions are independent of substrates and mediators.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
Y. Mao, D. Liu, S. Wang, S. Luo, W. Wang, Y. Yang, Q. Ouyang, and L. Jiang
Alternating-electric-field-enhanced reversible switching of DNA nanocontainers with pH
Nucleic Acids Res., March 12, 2007; 35(5): e33 - e33.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.