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Published online 31 March 2004

Nucleic Acids Research, 2004, Vol. 32, No. 6 1993-1999
© 2004 Oxford University Press

ESF1 is required for 18S rRNA synthesis in Saccharomyces cerevisiae

Wen-Tao Peng1, Nevan J. Krogan1,2, Dawn P. Richards3, Jack F. Greenblatt1,2 and Timothy R. Hughes*,1,2

1 Banting and Best Department of Medical Research, University of Toronto, 112 College Street, Toronto, Ontario M5G 1L6, Canada, 2 Department of Medical Genetics and Microbiology, University of Toronto, 1 Kings College Circle, Toronto, Ontario M5S 1A8, Canada and 3 Affinium Pharmaceuticals, 100 University Avenue, 10th Floor, Toronto, Ontario M5J 1V6, Canada

*To whom correspondence should be addressed. Tel: +1 416 946 8260; Fax: +1 416 978 8528; Email: t.hughes{at}utoronto.ca

Received February 18, 2004; Revised and Accepted March 10, 2004

We report that Esf1p (Ydr365cp), an essential, evolutionarily conserved nucleolar protein, is required for the biogenesis of 18S rRNA in Saccharomyces cerevisiae. Depletion of Esf1p resulted in delayed processing of 35S precursor and a striking loss of 18S rRNA. Esf1p physically associated with ribosomal proteins and proteins involved in 18S rRNA biogenesis. Consistent with its role in 18S rRNA biogenesis, Esf1p also physically associated with U3 and U14 snoRNAs, but did not appear to be a core component of the SSU processome. These data indicate that Esf1p plays a direct role in early pre-rRNA processing.


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