Nucleic Acids Research, 2004, Vol. 32, Database issue D138-D141
© 2004 Oxford University Press
The Pfam protein families database
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK, 1 Center for Genomics and Bioinformatics, Karolinska Institutet, S-171 77 Stockholm, Sweden and 2 Howard Hughes Medical Institute and Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
*To whom correspondence should be addressed. Tel: +44 1223 494950; Fax: +44 1223 494919; Email: agb{at}sanger.ac.uk
Pfam is a large collection of protein families and domains. Over the past 2 years the number of families in Pfam has doubled and now stands at 6190 (version 10.0). Methodology improvements for searching the Pfam collection locally as well as via the web are described. Other recent innovations include modelling of discontinuous domains allowing Pfam domain definitions to be closer to those found in structure databases. Pfam is available on the web in the UK (http://www.sanger.ac.uk/Software/Pfam/), the USA (http://pfam.wustl.edu/), France (http://pfam.jouy.inra.fr/) and Sweden (http://Pfam.cgb.ki.se/).
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