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Nucleic Acids Research, 2004, Vol. 32, Database issue D165-D167
© 2004 Oxford University Press

Update of NUREBASE: nuclear hormone receptor functional genomics

David Ruau, Jorge Duarte, Tarik Ourjdal, Guy Perrière1, Vincent Laudet and Marc Robinson-Rechavi*

Laboratoire de Biologie Moléculaire de la Cellule, CNRS UMR 5161, Ecole Normale Supérieure de Lyon, 46 allée d’Italie, 69364 Lyon Cedex 07, France and 1 Laboratoire de Biométrie et Biologie Evolutive, CNRS UMR 5558, Université Claude Bernard, Lyon 1, 43 boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France

*To whom correspondence should be addressed at present address: Joint Center for Structural Genomics, UCSD, 9500 Gilman Drive, La Jolla, CA 92093-0527, USA. Tel: +1 858 646 3100; Fax: +1 858 646 3171; Email: marc.robinson{at}ens-lyon.fr
The authors wish it to be known that, in their opinion, the first three authors should be regarded as joint First Authors

Nuclear hormone receptors are an abundant class of ligand-activated transcriptional regulators, found in varying numbers in all animals. Based on our experience of managing the official nomenclature of nuclear receptors, we have developed NUREBASE, a database containing protein and DNA sequences, reviewed protein alignments and phylogenies, taxonomy and annotations for all nuclear receptors. New developments in NUREBASE include explicit declaration of alternative transcripts of each gene, and expression data for human and mouse nuclear receptors. The core of NUREBASE is reviewed, and it is completed by NUREBASE_DAILY, automatically updated every 24 h. All information on accessing and installing NUREBASE may be found at http://www. ens-lyon.fr/LBMC/laudet/nurebase/nurebase.html.


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