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Nucleic Acids Research, 2004, Vol. 32, Database issue D344-D346
© 2004 Oxford University Press

TcruziDB: an integrated Trypanosoma cruzi genome resource

Michael Luchtan1,2, Chetna Warade2, D. Brent Weatherly1, Wim M. Degrave3, Rick L. Tarleton1,4 and Jessica C. Kissinger*,1,5

1 Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602-2606, USA, 2 Department of Computer Science, University of Georgia, Athens, GA 30602, USA, 3 Department of Biochemistry and Molecular Biology, Oswaldo Cruz Institute, Rio de Janeiro, RJ 21045-900, Brazil, 4 Department of Cellular Biology, University of Georgia, Athens, GA 30602-2607, USA and 5 Department of Genetics, University of Georgia, Athens, GA 30602-7223, USA

*To whom correspondence should be addressed. Tel: +1 706 542 6562; Fax: +1 706 542 3582; Email: jkissing{at}uga.edu

TcruziDB (http://TcruziDB.org) is an integrated genome database for the parasitic organism Trypanosoma cruzi, the causative agent of Chagas’ disease. The database currently incorporates all available sequence data (Genomic, BAC, EST) in a single user-friendly location. The database contains a variety of tools specifically designed for searching unannotated draft sequence via BLAST, keyword searches of pre-computed BLAST results, and protein motif searches. Release 1.0 of the database contains nearly 730 million bp of genome sequence from 1.1 million sequence reads generated by the TIGR–Karolinska–SBRI Trypanosoma cruzi Genome Consortium and 15 million bp of clustered EST and genomic sequence obtained from other sources. As annotation, microarray and proteomic data become available, the database will incorporate and integrate these data using the GUS (http://www.gusdb. org) relational framework.


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