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Nucleic Acids Research, 2004, Vol. 32, Database issue D411-D417
© 2004 Oxford University Press

WormBase: a multi-species resource for nematode biology and genomics

Todd W. Harris*, Nansheng Chen, Fiona Cunningham, Marcela Tello-Ruiz, Igor Antoshechkin1, Carol Bastiani1, Tamberlyn Bieri2, Darin Blasiar2, Keith Bradnam3, Juancarlos Chan1, Chao-Kung Chen3, Wen J. Chen1, Paul Davis3, Eimear Kenny1, Ranjana Kishore1, Daniel Lawson3, Raymond Lee1, Hans-Michael Muller1, Cecilia Nakamura1, Philip Ozersky2, Andrei Petcherski1, Anthony Rogers3, Aniko Sabo2, Erich M. Schwarz1, Kimberly Van Auken1, Qinghua Wang1, Richard Durbin3, John Spieth2, Paul W. Sternberg1 and Lincoln D. Stein

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA, 1 Howard Hughes Medical Institute and California Institute of Technology, Pasadena, CA, USA, 2 Genome Sequencing Center, Washington University, St Louis, MO, USA and 3 The Wellcome Trust Sanger Institute, Hinxton, UK

*To whom correspondence should be addressed. Tel: +1 516 367 6904; Fax: +1 516 367 8389; Email: harris{at}cshl.org
The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors

WormBase (http://www.wormbase.org/) is the central data repository for information about Caenorhabditis elegans and related nematodes. As a model organism database, WormBase extends beyond the genomic sequence, integrating experimental results with extensively annotated views of the genome. The WormBase Consortium continues to expand the biological scope and utility of WormBase with the inclusion of large-scale genomic analyses, through active data and literature curation, through new analysis and visualization tools, and through refinement of the user interface. Over the past year, the nearly complete genomic sequence and comparative analyses of the closely related species Caenorhabditis briggsae have been integrated into WormBase, including gene predictions, ortholog assignments and a new synteny viewer to display the relationships between the two species. Extensive site-wide refinement of the user interface now provides quick access to the most frequently accessed resources and a consistent browsing experience across the site. Unified single-page views now provide complete summaries of commonly accessed entries like genes. These advances continue to increase the utility of WormBase for C.elegans researchers, as well as for those researchers exploring problems in functional and comparative genomics in the context of a powerful genetic system.


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