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Nucleic Acids Research, 2004, Vol. 32, Database issue D449-D451
© 2004 Oxford University Press

The Database of Interacting Proteins: 2004 update

Lukasz Salwinski1,2, Christopher S. Miller2,3, Adam J. Smith2, Frank K. Pettit2, James U. Bowie2,3 and David Eisenberg*,1,2,3,4

1 Howard Hughes Medical Institute, 2 UCLA-DOE Institute for Genomics and Proteomics, 3 Department of Chemistry and Biochemistry and 4 Department of Biological Chemistry, Molecular Biology Institute, Box 951570, UCLA, Los Angeles, CA 90095-1570, USA

*To whom correspondence should be addressed. Tel: +1 310 825 3754; Fax: +1 310 206 3914; Email: david{at}mbi.ucla.edu

The Database of Interacting Proteins (http://dip.doe-mbi.ucla.edu) aims to integrate the diverse body of experimental evidence on protein–protein interactions into a single, easily accessible online database. Because the reliability of experimental evidence varies widely, methods of quality assessment have been developed and utilized to identify the most reliable subset of the interactions. This CORE set can be used as a reference when evaluating the reliability of high-throughput protein–protein interaction data sets, for development of prediction methods, as well as in the studies of the properties of protein interaction networks.


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