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Nucleic Acids Research, 2004, Vol. 32, Database issue D468-D470
© 2004 Oxford University Press

Ensembl 2004

E. Birney1, D. Andrews, P. Bevan, M. Caccamo, G. Cameron1, Y. Chen1, L. Clarke, G. Coates, T. Cox, J. Cuff, V. Curwen, T. Cutts, T. Down, R. Durbin, E. Eyras, X. M. Fernandez-Suarez1, P. Gane, B. Gibbins, J. Gilbert, M. Hammond1, H. Hotz, V. Iyer, A. Kahari1, K. Jekosch, A. Kasprzyk1, D. Keefe1, S. Keenan, H. Lehvaslaiho1, G. McVicker1, C. Melsopp1, P. Meidl, E. Mongin1, R. Pettett, S. Potter, G. Proctor, M. Rae1, S. Searle, G. Slater1, D. Smedley1, J. Smith, W. Spooner, A. Stabenau1, J. Stalker, R. Storey, A. Ureta-Vidal1, C. Woodwark1, M. Clamp and T. Hubbard*

Wellcome Trust Sanger Institute and 1 European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK

*To whom correspondence should be addressed. Tel: +44 1223 494983; Fax: +44 1223 494919; Email: th{at}sanger.ac.uk

The Ensembl (http://www.ensembl.org/) database project provides a bioinformatics framework to organize biology around the sequences of large genomes. It is a comprehensive and integrated source of annotation of large genome sequences, available via interactive website, web services or flat files. As well as being one of the leading sources of genome annotation, Ensembl is an open source software engineering project to develop a portable system able to handle very large genomes and associated requirements. The facilities of the system range from sequence analysis to data storage and visualization and installations exist around the world both in companies and at academic sites. With a total of nine genome sequences available from Ensembl and more genomes to follow, recent developments have focused mainly on closer integration between genomes and external data.


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