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Nucleic Acids Research, 2004, Vol. 32, Database issue D64-D69
© 2004 Oxford University Press

ASD: the Alternative Splicing Database

T. A. Thanaraj*, Stefan Stamm1, Francis Clark2, Jean-Jack Riethoven, Vincent Le Texier and Juha Muilu

European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, 1 University of Erlangen Nurenberg, Institute for Biochemistry, Fahrstrasse 17, 91054 Erlangen, Germany and 2 Advanced Computational Modelling Centre, University of Queensland, St Lucia, 4072, Australia

*To whom correspondence should be addressed. Tel: +44 1223 494650; Fax: +44 1223 494468; Email: thanaraj{at}ebi.ac.uk
Present address:
Juha Muilu, Finnish Genome Centre, PO Box 63, 00014 Helsinki, Finland

Alternative splicing is widespread in mammalian gene expression, and variant splice patterns are often specific to different stages of development, particular tissues or a disease state. There is a need to systematically collect data on alternatively spliced exons, introns and splice isoforms, and to annotate this data. The Alternative Splicing Database consortium has been addressing this need, and is committed to maintaining and developing a value-added database of alternative splice events, and of experimentally verified regulatory mechanisms that mediate splice variants. In this paper we present two of the products from this project: namely, a database of computationally delineated alternative splice events as seen in alignments of EST/cDNA sequences with genome sequences, and a database of alternatively spliced exons collected from literature. The reported splice events are from nine different organisms and are annotated for various biological features including expression states and cross-species conservation. The data are presented on our ASD web pages (http://www.ebi.ac.uk/asd).


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