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Nucleic Acids Research, 2004, Vol. 32, Database issue D86-D90
© 2004 Oxford University Press

HemoPDB: Hematopoiesis Promoter Database, an information resource of transcriptional regulation in blood cell development

Twyla T. Pohar, Hao Sun and Ramana V. Davuluri*

Division of Human Cancer Genetics, Comprehensive Cancer Center, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, OH 43210, USA

*To whom correspondence should be addressed at 420 West 12th Avenue, TMRF 524, Columbus, OH 43210, USA. Tel: +1 614 688 3088; Fax: +1 614 688 4006; Email: Davuluri-1{at}medctr.osu.edu

Hematopoiesis describes the process of the normal formation and development of blood cells, involving both proliferation and differentiation from stem cells. Abnormalities in this developmental program yield blood cell diseases, such as leukemia. Although, in recent years, extensive molecular research in normal hematopoietic development has characterized transcription factors and their binding sites in the target gene promoters, the information generated is highly fragmented. In order to integrate this important regulatory information with the corresponding genomic sequences, we have developed a new database called Hematopoiesis Promoter Database (HemoPDB). HemoPDB is a comprehensive resource focused on transcriptional regulation during hematopoietic development and associated aberrances that result in malignancy. HemoPDB (version 1.0) contains 246 promoter sequences and 604 experimentally known cis-regulatory elements of 187 different transcription factors, with links to published references. Orthologous promoters from different species are linked with each other and displayed in the same database record, accompanied by a visual image of the promoters and corresponding annotations of cis-regulatory elements. HemoPDB may be searched for the promoter of a specific gene, transcription factors and target genes, and genes that are expressed in a certain cell type or lineage, through a user-friendly web interface at http://bioinformatics.med.ohio-state.edu/HemoPDB. Links to the documentation and other technical details are provided on this website.


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