PromoSer: improvements to the algorithm, visualization and accessibility
1 Bioinformatics Program and 2 Biomedical Engineering Department, Boston University, 44 Cummington Street, Boston, MA 02215, USA
* To whom correspondence should be addressed. Tel: +1 617 353 3509; Fax: +1 617 353 6766; Email: zhiping{at}bu.edu
Received February 15, 2004; Revised March 19, 2004; Accepted April 13, 2004
PromoSer is a web service that provides an easy and efficient approach to the batch retrieval of a large number of proximal promoters. Since its introduction last year, it has undergone continued development and expansion. At the core, there have been improvements in the filtering of the raw mRNA/EST sequences upon which all predictions are built, improvements in the alignments clustering and transcription start site prediction algorithms, and improvements in the backing database for increased performance. At the user interface level, improvements include enhanced functionality and user options, better integration with other resources on the web and a new visualization tool. PromoSer now also supports queries using a SOAP-based interface and XML-based responses. The service is publicly available at http://biowulf.bu.edu/zlab/PromoSer.
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