InterWeaver: interaction reports for discovering potential protein interaction partners with online evidence
Knowledge Discovery Department, Institute for Infocomm Research, 21 Heng Mui Keng Terrace, Singapore 119613
* To whom correspondence should be addressed. Tel: +65 68748809; Fax: +65 67748056; Email: zzhang{at}i2r.a-star.edu.sg
Received February 6, 2004; Revised March 18, 2004; Accepted April 15, 2004
InterWeaver is a web server for discovering potential protein interactions with online evidence automatically extracted from protein interaction databases, literature abstracts, domain fusion events and domain interactions. Given a new protein sequence, the server identifies potential interaction partners using two approaches. In the homology-based approach, the system performs sequence homology searches to find similar proteins in other species, and then searches the protein interaction databases and the biomedical literature for interaction partners. In the domain-based approach, the system detects the domains in the input protein sequence and searches databases of domain fusion events and putative domain interactions to suggest potential interacting partners. The results are compiled into a personalized and downloadable interaction report to aid biologists in their discovery of protein interactions. InterWeaver is freely available for academic users at http://interweaver.i2r.a-star.edu.sg/.
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