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Nucleic Acids Research 2005 33(13):4276-4284; doi:10.1093/nar/gki738
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Published online 28 July 2005

© The Author 2005. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oupjournals.org

Article

FAST DB: a website resource for the study of the expression regulation of human gene products

Pierre de la Grange, Martin Dutertre, Natalia Martin and Didier Auboeuf*

INSERM U685/AVENIR, Centre G. Hayem, Institut Universitaire d'Hématologiem, Hôpital Saint Louis 1 Avenue Claude Vellefaux, 75010 Paris, France

*To whom correspondence should be addressed. Tel: +33 1 53 72 21 30; Fax: +33 1 42 40 95 57; Email: auboeuf{at}stlouis.inserm.fr

Received May 18, 2005. Revised July 11, 2005. Accepted July 11, 2005.

Human genes use various mechanisms to generate different transcripts having different exon content, which in turn generate multiple protein isoforms having differential and even opposite biological activities. To understand the biological consequences of gene transcriptional activity modulation, it is necessary to integrate the capability of genes to generate distinct functional products, particularly because transcriptional stimuli also affect the exon content of their target gene products. For this purpose, we have developed a bioinformatics suite, FAST DB, which defines easily and accurately the exon content of all known transcripts produced by human genes. In addition, several tools have been developed, including a graphical presentation of all gene products, a sequence multi-alignment of all gene transcripts and an in silico PCR computer program. The FAST DB interface also offers extensive links to website resources for promoter analysis and transcription factor binding site prediction, splicing regulatory sequence prediction, as well as 5'- and 3'-untranslated region analysis. FAST DB has been designed to facilitate studies that integrate transcriptional and post-transcriptional events to investigate the expression regulation of human gene products.


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