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Nucleic Acids Research 2005 33(14):4618-4625; doi:10.1093/nar/gki744
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Published online 15 August 2005

© The Author 2005. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oupjournals.org

Article

DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLE

Stephen Malin, Ylva Linderson, Jenny Almqvist, Ingemar Ernberg, Tiziano Tallone and Sven Pettersson*

Department of Microbiology and Tumor biology Box 280, Karolinska Institutet, 171 77 Stockholm, Sweden

*To whom correspondence should be addressed. Tel: +46 8 524 86686; Fax: +46 8 331547; Email: sven.pettersson{at}mtc.ki.se

Received April 5, 2005. Revised May 23, 2005. Accepted July 12, 2005.

POU domain proteins contain a bipartite DNA-binding element that can confer allosteric control of coactivator recruitment. Dimerization of Oct-1 and Oct-2 on palindromic response elements results in the conformational dependent inclusion or exclusion of the transcriptional coactivator OBF-1. In this paper, we demonstrate that Oct-1 and Oct-2 can function as transcriptional repressors by recruiting and physically interacting with members of the Grg/TLE family of corepressors. In accordance with a model of DNA induced cofactor assembly, and analogous to the recruitment of the OBF-1 coactivator, the different Grg/TLE members can discriminate between both Oct-1 and Oct-2, and the monomeric or dimeric nature of the POU/DNA complex.

Present addresses: Stephen Malin, Institute for Molecular Pathology (IMP), Dr Bohr-Gasse 7 1030 Vienna, Austria

Tiziano Tallone, Biochemistry Institute, Université de Fribourg, Pérolles CH-1700 Fribourg, Switzerland


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