Published online 3 January 2006
Survey and Summary |
AU-rich elements and associated factors: are there unifying principles?
UMR 6061 CNRS Génétique et Développement, IFR 140 Génétique Fonctionnelle Agronomie et Santé, Université de Rennes 1, Faculté de Médecine CS 34317, 35043 Rennes cedex, France
*To whom correspondence should be addressed. Tel: +33 223 23 4523; Fax: +33 223 23 4478; Email: Beverley.osborne{at}univ-rennes1.fr
Received September 17, 2005. Revised November 5, 2005. Accepted November 25, 2005.
The control of mRNA stability is an important process that allows cells to not only limit, but also rapidly adjust, the expression of regulatory factors whose over expression may be detrimental to the host organism. Sequence elements rich in A and U nucleotides or AU-rich elements (AREs) have been known for many years to target mRNAs for rapid degradation. In this survey, after briefly summarizing the data on the sequence characteristics of AREs, we present an analysis of the known ARE-binding proteins (ARE-BP) with respect to their mRNA targets and the consequences of their binding to the mRNA. In this analysis, both the changes in mRNA stability and the lesser studied effects on translation are considered. This analysis highlights the multitude of mRNAs bound by one ARE-BP and conversely the large number of ARE-BP that associate with any particular ARE-containing mRNA. This situation is discussed with respect to functional redundancies or antagonisms. The potential relationship between mRNA stability and translation is also discussed. Finally, we present several hypotheses that could unify the published data and suggest avenues for future research.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. M. Perry, S. A. Moschos, A. E. Williams, N. J. Shepherd, H. M. Larner-Svensson, and M. A. Lindsay Rapid Changes in MicroRNA-146a Expression Negatively Regulate the IL-1{beta}-Induced Inflammatory Response in Human Lung Alveolar Epithelial Cells J. Immunol., April 15, 2008; 180(8): 5689 - 5698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kitamura, M. Ito, T. Yuasa, C. Kikuguchi, A. Hijikata, M. Takayama, Y. Kimura, R. Yokoyama, T. Kaji, and O. Ohara Genome-wide identification and characterization of transcripts translationally regulated by bacterial lipopolysaccharide in macrophage-like J774.1 cells Physiol Genomics, March 10, 2008; 33(1): 121 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Suswam, Y. Li, X. Zhang, G. Y. Gillespie, X. Li, J. J. Shacka, L. Lu, L. Zheng, and P. H. King Tristetraprolin Down-regulates Interleukin-8 and Vascular Endothelial Growth Factor in Malignant Glioma Cells Cancer Res., February 1, 2008; 68(3): 674 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ezzeddine, T.-C. Chang, W. Zhu, A. Yamashita, C.-Y. A. Chen, Z. Zhong, Y. Yamashita, D. Zheng, and A.-B. Shyu Human TOB, an Antiproliferative Transcription Factor, Is a Poly(A)-Binding Protein-Dependent Positive Regulator of Cytoplasmic mRNA Deadenylation Mol. Cell. Biol., November 15, 2007; 27(22): 7791 - 7801. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Hartmann, C. Benz, S. Brems, L. Ellis, V.-D. Luu, M. Stewart, I. D'Orso, C. Busold, K. Fellenberg, A. C. C. Frasch, et al. Small Trypanosome RNA-Binding Proteins TbUBP1 and TbUBP2 Influence Expression of F-Box Protein mRNAs in Bloodstream Trypanosomes Eukaryot. Cell, November 1, 2007; 6(11): 1964 - 1978. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Narsai, K. A. Howell, A. H. Millar, N. O'Toole, I. Small, and J. Whelan Genome-Wide Analysis of mRNA Decay Rates and Their Determinants in Arabidopsis thaliana PLANT CELL, November 1, 2007; 19(11): 3418 - 3436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Vinogradov and O. V. Anatskaya Organismal complexity, cell differentiation and gene expression: human over mouse Nucleic Acids Res., October 8, 2007; 35(19): 6350 - 6356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lu, L. Zheng, L. Viera, E. Suswam, Y. Li, X. Li, A. G. Estevez, and P. H. King Mutant Cu/Zn-Superoxide Dismutase Associated with Amyotrophic Lateral Sclerosis Destabilizes Vascular Endothelial Growth Factor mRNA and Downregulates Its Expression J. Neurosci., July 25, 2007; 27(30): 7929 - 7938. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Korhonen, K. Linker, A. Pautz, U. Forstermann, E. Moilanen, and H. Kleinert Post-Transcriptional Regulation of Human Inducible Nitric-Oxide Synthase Expression by the Jun N-terminal Kinase Mol. Pharmacol., May 1, 2007; 71(5): 1427 - 1434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Murray and D. R. Schoenberg A+U-Rich Instability Elements Differentially Activate 5'-3' and 3'-5' mRNA Decay Mol. Cell. Biol., April 15, 2007; 27(8): 2791 - 2799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bevilacqua, L. Ghisolfi, S. Franzi, G. Maresca, R. Gherzi, S. Capaccioli, A. Nicolin, and G. Canti Stabilization of Cellular mRNAs and Up-Regulation of Proteins by Oligoribonucleotides Homologous to the Bcl2 Adenine-Uridine Rich Element Motif Mol. Pharmacol., February 1, 2007; 71(2): 531 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Forest, R. Nishikawa, H. Kobayashi, A. Parton, C. J. Bayne, and D. W. Barnes RNA expression in a cartilaginous fish cell line reveals ancient 3' noncoding regions highly conserved in vertebrates PNAS, January 23, 2007; 104(4): 1224 - 1229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kubo, T. Wada, Y. Yamaguchi, A. Shimizu, and H. Handa Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3'-UTRs Nucleic Acids Res., December 4, 2006; 34(21): 6264 - 6271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Banerjee, M. Chatterjee, Y. Yu, S.-G. Suh, W. A. Miller, and D. J. Hannapel Dynamics of a Mobile RNA of Potato Involved in a Long-Distance Signaling Pathway PLANT CELL, December 1, 2006; 18(12): 3443 - 3457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. K. Lee and S. Jeong {beta}-Catenin stabilizes Cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3'-UTR Nucleic Acids Res., November 14, 2006; 34(19): 5705 - 5714. [Abstract] [Full Text] [PDF]
|
|