Skip Navigation

Nucleic Acids Research 2005 33(3):1077-1086; doi:10.1093/nar/gki250
This Article
Right arrow Full Text Freely available
Right arrow Print PDF (581K) Freely available
Right arrow Screen PDF (602K) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (2)
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Dyer, K. D.
Right arrow Articles by Rosenberg, H. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dyer, K. D.
Right arrow Articles by Rosenberg, H. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published online 18 February 2005

© The Author 2005. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oupjournals.org

Article

The mouse RNase 4 and RNase 5/ang 1 locus utilizes dual promoters for tissue-specific expression

Kimberly D. Dyer* and Helene F. Rosenberg

Laboratory of Allergic Diseases NIAID, NIH, Bethesda, MD 20892, USA

*To whom correspondence should be addressed at 10 Center Drive MSC 1886, Building 10 Room 11C216, Bethesda, MD 20892-1886, USA. Tel: +1 301 402 429; Fax: +1 301 402 4369; Email: kdyer{at}niaid.nih.gov

Received November 19, 2004. Revised January 25, 2005. Accepted January 25, 2005.

The ribonuclease A (RNase A) superfamily has been the subject of extensive studies in the areas of protein evolution, structure and biochemistry and are exciting molecules in that they appear to be responding to unique selection pressures, generating proteins capable of multiple and diverse activities. The RNase 4 and RNase 5/ang 1 shared locus breaks a pattern that is otherwise canonical among the members of the RNase A gene superfamily. Conserved among humans, mice and rats, the locus includes two non-coding exons followed by two distinct exons encoding RNase 4 and RNase 5/ang 1. Transcription from this locus is controlled by differential splicing and tissue-specific expression from promoters located 5' to each of the non-coding exons. Promoter 1, 5' to exon I, is universally active, while Promoter 2, 5' to exon II, is active only in hepatic cells in promoter assays in vitro. Transcription from Promoter 2 is dependent on an intact HNF-1 consensus binding site which binds the transcription factor HNF-1{alpha}. In summary, RNase 4 and RNase 5/ang 1 are unique among the RNase A ribonuclease genes in that they maintain a complex gene locus that is conserved across species with transcription initiated from tissue-specific dual promoters followed by differential exon splicing.

DDBJ/EMBL/GenBank accession no. AY762362


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 JCBHome page
S. Yamasaki, P. Ivanov, G.-f. Hu, and P. Anderson
Angiogenin cleaves tRNA and promotes stress-induced translational repression
J. Cell Biol., April 6, 2009; 185(1): 35 - 42.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Inagaki, A. Moschetta, Y.-K. Lee, L. Peng, G. Zhao, M. Downes, R. T. Yu, J. M. Shelton, J. A. Richardson, J. J. Repa, et al.
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
PNAS, March 7, 2006; 103(10): 3920 - 3925.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.