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Nucleic Acids Research 2005 33(Database Issue):D230-D232; doi:10.1093/nar/gki029
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Nucleic Acids Research, 2005, Vol. 33, Database issue D230-D232
© 2005, the authors
Nucleic Acids Research, Vol. 33, Database issue © Oxford University Press 2005; all rights reserved

REBASE—restriction enzymes and DNA methyltransferases

Richard J. Roberts*, Tamas Vincze, Janos Posfai and Dana Macelis

New England Biolabs, Inc., 32 Tozer Road, Beverly, MA 01915 USA

* To whom correspondence should be addressed. Tel: +1 978 927 3382; Fax: +1 978 921 1527; Email: roberts{at}neb.com

Received September 17, 2004; Accepted September 22, 2004

REBASE is a comprehensive database of information about restriction enzymes, DNA methyltransferases and related proteins involved in restriction–modification. It contains both published and unpublished work with information about recognition and cleavage sites, isoschizomers, commercial availability, crystal and sequence data. Experimentally characterized homing endonucleases are also included. Additionally, REBASE contains complete and up-to-date information about the methylation sensitivity of restriction endonucleases. An extensive analysis is included of the restriction–modification systems that are predicted to be present in the sequenced bacterial and archaeal genomes from GenBank. The contents of REBASE are available by browsing from the web (http://rebase.neb.com/rebase/rebase.html) and through selected compilations by ftp (ftp.neb.com) and as monthly updates that can be requested via email.

The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use permissions, please contact journals.permissions{at}oupjournals.org.


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