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Nucleic Acids Research 2005 33(Database Issue):D321-D324; doi:10.1093/nar/gki042
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Nucleic Acids Research, 2005, Vol. 33, Database issue D321-D324
© 2005, the authors
Nucleic Acids Research, Vol. 33, Database issue © Oxford University Press 2005; all rights reserved

Metagrowth: a new resource for the building of metabolic hypotheses in microbiology

Hiroyuki Ogata* and Jean-Michel Claverie

Information Génomique et Structurale, CNRS UPR 2589, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France

* To whom correspondence should be addressed. Tel: +33 491 16 45 48; Fax: +33 491 16 45 49; Email: Hiroyuki.Ogata{at}igs.cnrs-mrs.fr

Received August 7, 2004; Revised and Accepted September 28, 2004

Metagrowth is a new type of knowledge base developed to guide the experimental studies of culture conditions of obligate parasitic bacteria. We have gathered biological evidences giving possible clues to the development of the axenic (i.e. ‘cell-free’) growth of obligate parasites from various sources including published literature, genomic sequence information, metabolic databases and transporter databases. The database entries are composed of those evidences and specific hypotheses derived from them. Currently, 200 entries are available for Rickettsia prowazekii, Rickettsia conorii, Tropheryma whipplei, Treponema pallidum, Mycobacterium tuberculosis and Coxiella burnetii. The web interface of Metagrowth helps users to design new axenic culture media eventually suitable for those bacteria. Metagrowth is accessible at http://igs-server.cnrs-mrs.fr/axenic/.

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