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Nucleic Acids Research 2005 33(Database Issue):D364-D368; doi:10.1093/nar/gki053
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Nucleic Acids Research, 2005, Vol. 33, Database issue D364-D368
© 2005, the authors
Nucleic Acids Research, Vol. 33, Database issue © Oxford University Press 2005; all rights reserved

CYGD: the Comprehensive Yeast Genome Database

U. Güldener1, M. Münsterkötter1, G. Kastenmüller1, N. Strack11, J. van Helden2, C. Lemer2, J. Richelles2, S. J. Wodak2, J. García-Martínez3, J. E. Pérez-Ortín3, H. Michael4, A. Kaps5, E. Talla6, B. Dujon7, B. André8, J. L. Souciet9, J. De Montigny9, E. Bon10, C. Gaillardin10 and H. W. Mewes1,11,*

1 Institute for Bioinformatics, GSF National Research Center for Environment and Health, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany, 2 Service de Conformation des Macromolécules Biologiques et Bioinformatique, Université Libre de Bruxelles, CP 263, Blvd du Triomphe, B-1050 Bruxelles, Belgium, 3 Departamento de Bioquímica y Biología Molecular, Universitat de València, C/Dr Moliner 50, E-46100 Burjassot, Spain, 4 Department of Bioinformatics, UKG, University of Göttingen, Goldschmidtstrasse 1, D-37077 Göttingen, Germany, 5 Biomax Informatics AG, Lochhamerstrasse 11, 82152 Martinsried, Germany, 6 CNRS-LCB, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France, 7 Unité de Génétique moléculaire des levures (URA 2171 CNRS and UFR 927 Université Pierre and Marie Curie), Institut Pasteur, Paris, France, 8 Laboratoire de Physiologie cellulaire CP300, Universite Libre de Bruxelles, IBMM, rue des Pr. Jeener et Brachet, 12, 6041 Gosselies, Belgium, 9 Laboratoire de Dynamique, Evolution et Expression des Génomes de Microorganismes, Université Louis Pasteur/CNRS, FRE 2326, 28 rue Goethe, 67000 Strasbourg, France, 10 Laboratoire de Génétique Moléculaire et Cellulaire (URA 1925 CNRS and UMR 216 INRA), INA-PG PO Box 01, F-78850 Thiverval Grignon, France and 11 Technische Universität München, Chair of Genome Oriented Bioinformatics, Center of Life and Food Science, D-85350 Freising-Weihenstephan, Germany

* To whom correspondence should be addressed. Tel: +49 89 3187 3580; Fax: +49 89 3187 3585; Email: w.mewes{at}gsf.de
Present address: E. Bon, CBiB–Centre de Bioinformatique de Bordeaux/LBMA–Laboratoire de Biotechnologie et Microbiologie Appliquée, Faculté d'Oenologie, Université Victor Segalen (Bordeaux 2), 146 rue Léo Saignat, F-33076 Bordeaux Cedex, France
The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors

Received August 10, 2004; Revised and Accepted October 1, 2004

The Comprehensive Yeast Genome Database (CYGD) compiles a comprehensive data resource for information on the cellular functions of the yeast Saccharomyces cerevisiae and related species, chosen as the best understood model organism for eukaryotes. The database serves as a common resource generated by a European consortium, going beyond the provision of sequence information and functional annotations on individual genes and proteins. In addition, it provides information on the physical and functional interactions among proteins as well as other genetic elements. These cellular networks include metabolic and regulatory pathways, signal transduction and transport processes as well as co-regulated gene clusters. As more yeast genomes are published, their annotation becomes greatly facilitated using S.cerevisiae as a reference. CYGD provides a way of exploring related genomes with the aid of the S.cerevisiae genome as a backbone and SIMAP, the Similarity Matrix of Proteins. The comprehensive resource is available under http://mips.gsf.de/genre/proj/yeast/.

The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use permissions, please contact journals.permissions{at}oupjournals.org.


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