Nucleic Acids Research, 2005, Vol. 33, Database issue D505-D510
© 2005, the authors
Nucleic Acids Research, Vol. 33, Database issue © Oxford University Press 2005; all rights reserved
DG-CST (Disease Gene Conserved Sequence Tags), a database of human–mouse conserved elements associated to disease genes
1 CEINGE Biotecnologie Avanzate, 2 Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy, 3 FIRC Institute of Molecular Oncology Foundation (IFOM), 4 Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita' di Milano, Milan, Italy, 5 Dipartimento di Scienze Animali, Vegetali e dell'Ambiente, Universita' del Molise, Campobasso, Italy, 6 BioGeM Consortium and 7 Medical Genetics, Department of Pediatrics, Federico II University, Naples, Italy
* To whom correspondence should be addressed. Tel: +39 081 6132206; Fax: +39 081 5609877; Email: banfi{at}tigem.it
The authors wish it to be known that, in their opinion, the first three authors should be regarded as joint First Authors
Received August 6, 2004; Revised and Accepted September 14, 2004
The identification and study of evolutionarily conserved genomic sequences that surround disease-related genes is a valuable tool to gain insight into the functional role of these genes and to better elucidate the pathogenetic mechanisms of disease. We created the DG-CST (Disease Gene Conserved Sequence Tags) database for the identification and detailed annotation of human–mouse conserved genomic sequences that are localized within or in the vicinity of human disease-related genes. CSTs are defined as sequences that show at least 70% identity between human and mouse over a length of at least 100 bp. The database contains CST data relative to over 1088 genes responsible for monogenetic human genetic diseases or involved in the susceptibility to multifactorial/polygenic diseases. DG-CST is accessible via the internet at http://dgcst.ceinge.unina.it/ and may be searched using both simple and complex queries. A graphic browser allows direct visualization of the CSTs and related annotations within the context of the relative gene and its transcripts.
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