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Nucleic Acids Research 2005 33(Web Server Issue):W347-W351; doi:10.1093/nar/gki411
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© The Author 2005. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oupjournals.org

Article

EVAcon: a protein contact prediction evaluation service

Osvaldo Graña, Volker A. Eyrich1, Florencio Pazos, Burkhard Rost1 and Alfonso Valencia*

Protein Design Group, Centro Nacional de Biotecnologia (CNB-CSIC) Cantoblanco, 28049 Madrid, Spain 1CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University 650 West 168th Street BB217, New York, NY 10032, USA

*To whom correspondence should be addressed. Tel: +34 91 585 4570; Fax: +34 91 585 4506; Email: valencia{at}cnb.uam.es

Received February 14, 2005. Revised March 21, 2005. Accepted March 21, 2005.

Here we introduce EVAcon, an automated web service that evaluates the performance of contact prediction servers. Currently, EVAcon is monitoring nine servers, four of which are specialized in contact prediction and five are general structure prediction servers. Results are compared for all newly determined experimental structures deposited into PDB (~5–50 per week). EVAcon allows for a precise comparison of the results based on a system of common protein subsets and the commonly accepted evaluation criteria that are also used in the corresponding category of the CASP assessment. EVAcon is a new service added to the functionality of the EVA system for the continuous evaluation of protein structure prediction servers. The new service is accesible from any of the three EVA mirrors: PDG (CNB-CSIC, Madrid) (http://www.pdg.cnb.uam.es/eva/con/index.html); CUBIC (Columbia University, NYC) (http://cubic.bioc.columbia.edu/eva/con/index.html); and Sali Lab (UCSF, San Francisco) (http://eva.compbio.ucsf.edu/~eva/con/index.html).


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