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Nucleic Acids Research 2006 34(1):66-77; doi:10.1093/nar/gkj412
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Published online 10 January 2006

© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oxfordjournals.org

Article

Dispersal and regulation of an adaptive mutagenesis cassette in the bacteria domain

Ivan Erill, Susana Campoy1, Gerard Mazon1 and Jordi Barbé1,2,*

Biomedical Applications Group, Centro Nacional de Microelectrónica 08193 Bellaterra, Spain 1Centre de Recerca en Sanitat Animal (CReSA) 08193 Bellaterra, Spain 2Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona 08193 Bellaterra Spain

*To whom correspondence should be addressed at Departament de Genètica i Microbiologia, Ed. C, Universitat Autònoma de Barcelona 08193 Bellaterra, Spain. Tel: +34 93 581 1837; Fax: +34 93 581 2387; Email: jordi.barbe{at}uab.es

Received September 30, 2005. Revised December 8, 2005. Accepted December 8, 2005.

Recently, a multiple gene cassette with mutagenic translation synthesis activity was identified and shown to be under LexA regulation in several proteobacteria species. In this work, we have traced down instances of this multiple gene cassette across the bacteria domain. Phylogenetic analyses show that this cassette has undergone several reorganizations since its inception in the actinobacteria, and that it has dispersed across the bacterial domain through a combination of vertical inheritance, lateral gene transfer and duplication. In addition, our analyses show that LexA regulation of this multiple gene cassette is persistent in all the phyla in which it has been detected, and suggest that this regulation is prompted by the combined activity of two of its constituent genes: a polymerase V homolog and an alpha subunit of the DNA polymerase III.

The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors


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