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Nucleic Acids Research Advance Access originally published online on August 25, 2006
Nucleic Acids Research 2006 34(15):4138-4146; doi:10.1093/nar/gkl528
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Nucleic Acids Research, 2006, Vol. 34, No. 15 4138-4146
© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Coordination of DNA synthesis and replicative unwinding by the S-phase checkpoint pathways

Marina N. Nedelcheva-Veleva, Dragomir B. Krastev and Stoyno S. Stoynov*

Institute of Molecular Biology, Bulgarian Academy of Sciences 21 G. Bonchev Strasse Sofia 1113, Bulgaria

*To whom correspondence should be addressed. Tel: +359 979 36 89; Fax: +359 2 72 25 077; Email: stoynov{at}obzor.bio21.bas.bg

Received May 14, 2006. Revised July 8, 2006. Accepted July 10, 2006.

The process of DNA replication includes duplex unwinding, followed immediately by DNA synthesis. In eukaryotes, DNA synthesis is disturbed in damaged DNA regions, in replication slow zones, or as a result of insufficient nucleotide level. This review aims to discuss the mechanisms that coordinate DNA unwinding and synthesis, allowing replication to be completed even in the presence of genomic insults. There is a growing body of evidence which suggests that S-phase checkpoint pathways regulate both replicative unwinding and DNA synthesis, to synchronize the two processes, thus ensuring genome stability.


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