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Nucleic Acids Research Advance Access originally published online on September 13, 2006
Nucleic Acids Research 2006 34(17):4826-4836; doi:10.1093/nar/gkl656
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Nucleic Acids Research, 2006, Vol. 34, No. 17 4826-4836
© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Survey and Summary

Spatial organization of transcription by RNA polymerase III

Rebecca A. Haeusler and David R. Engelke*

Department of Biological Chemistry, University of Michigan, 1150 W. Medical Center Drive, 3200 MSRBIII, Ann Arbor MI 48109-0606, USA

*To whom correspondence should be addressed. Tel: +1 734 763 0641; Fax:+1 734 763 7799; Email: engelke{at}umich.edu

Received July 19, 2006. Revised August 22, 2006. Accepted August 24, 2006.

RNA polymerase III (pol III) transcribes many essential, small, noncoding RNAs, including the 5S rRNAs and tRNAs. While most pol III-transcribed genes are found scattered throughout the linear chromosome maps or in multiple linear clusters, there is increasing evidence that many of these genes prefer to be spatially clustered, often at or near the nucleolus. This association could create an environment that fosters the coregulation of transcription by pol III with transcription of the large ribosomal RNA repeats by RNA polymerase I (pol I) within the nucleolus. Given the high number of pol III-transcribed genes in all eukaryotic genomes, the spatial organization of these genes is likely to affect a large portion of the other genes in a genome. In this Survey and Summary we analyze the reports regarding the spatial organization of pol III genes and address the potential influence of this organization on transcriptional regulation.

The history dates have been corrected.


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