Nucleic Acids Research Advance Access originally published online on October 4, 2006
Nucleic Acids Research 2006 34(19):e130; doi:10.1093/nar/gkl707
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Nucleic Acids Research, 2006, Vol. 34, No. 19 e130
© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Methods Online |
Analysis of protein sequence and interaction data for candidate disease gene prediction
1 Computational Biology & Bioinformatics Program Sydney, NSW, Australia 2 Developmental Biology Program Sydney, NSW, Australia 3 Sr. Bernice Research Program in Inherited Heart Diseases, Victor Chang Cardiac Research Institute Sydney, NSW, Australia 4 School of Biotechnology & Biomolecular Sciences Sydney, NSW, Australia 5 School of Medicine, University of New South Wales Sydney, NSW, Australia 6 Cardiology Department, St. Vincent's Hospital Sydney, NSW, Australia
To whom correspondence should be addressed. Tel: +61 2 92958508; Fax: +61 2 9295 8501; Email: m.wouters{at}victorchang.unsw.edu.au
Received July 31, 2006. Revised September 12, 2006. Accepted September 13, 2006.
Linkage analysis is a successful procedure to associate diseases with specific genomic regions. These regions are often large, containing hundreds of genes, which make experimental methods employed to identify the disease gene arduous and expensive. We present two methods to prioritize candidates for further experimental study: Common Pathway Scanning (CPS) and Common Module Profiling (CMP). CPS is based on the assumption that common phenotypes are associated with dysfunction in proteins that participate in the same complex or pathway. CPS applies network data derived from protein–protein interaction (PPI) and pathway databases to identify relationships between genes. CMP identifies likely candidates using a domain-dependent sequence similarity approach, based on the hypothesis that disruption of genes of similar function will lead to the same phenotype. Both algorithms use two forms of input data: known disease genes or multiple disease loci. When using known disease genes as input, our combined methods have a sensitivity of 0.52 and a specificity of 0.97 and reduce the candidate list by 13-fold. Using multiple loci, our methods successfully identify disease genes for all benchmark diseases with a sensitivity of 0.84 and a specificity of 0.63. Our combined approach prioritizes good candidates and will accelerate the disease gene discovery process.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Chen, E. E. Bardes, B. J. Aronow, and A. G. Jegga ToppGene Suite for gene list enrichment analysis and candidate gene prioritization Nucleic Acids Res., July 1, 2009; 37(suppl_2): W305 - W311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Cai, E. Borenstein, R. Chen, and D. A. Petrov Similarly Strong Purifying Selection Acts on Human Disease Genes of All Evolutionary Ages Gen Biol Evol, June 22, 2009; 2009(0): 131 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ortutay and M. Vihinen Identification of candidate disease genes by integrating Gene Ontologies and protein-interaction networks: case study of primary immunodeficiencies Nucleic Acids Res., February 1, 2009; 37(2): 622 - 628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yilmaz, P. Jonveaux, C. Bicep, L. Pierron, M. Smail-Tabbone, and M.D. Devignes Gene-disease relationship discovery based on model-driven data integration and database view definition Bioinformatics, January 15, 2009; 25(2): 230 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Sparrow, E. Guillen-Navarro, D. Fatkin, and S. L. Dunwoodie Mutation of HAIRY-AND-ENHANCER-OF-SPLIT-7 in humans causes spondylocostal dysostosis Hum. Mol. Genet., December 1, 2008; 17(23): 3761 - 3766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-C. Tranchevent, R. Barriot, S. Yu, S. Van Vooren, P. Van Loo, B. Coessens, B. De Moor, S. Aerts, and Y. Moreau ENDEAVOUR update: a web resource for gene prioritization in multiple species Nucleic Acids Res., July 1, 2008; 36(suppl_2): W377 - W384. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Feldman, A. Rzhetsky, and D. Vitkup Network properties of genes harboring inherited disease mutations PNAS, March 18, 2008; 105(11): 4323 - 4328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Kann Protein interactions and disease: computational approaches to uncover the etiology of diseases Brief Bioinform, September 1, 2007; 8(5): 333 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Perez-Iratxeta, P. Bork, and M. A. Andrade-Navarro Update of the G2D tool for prioritization of gene candidates to inherited diseases Nucleic Acids Res., July 13, 2007; 35(suppl_2): W212 - W216. [Abstract] [Full Text] [PDF]
|
|