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Nucleic Acids Research 2006 34(2):659-666; doi:10.1093/nar/gkj472
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Published online 1 February 2006

© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oxfordjournals.org

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Degradation of RNA in bacteria: comparison of mRNA and stable RNA

Murray P. Deutscher*

Department of Biochemistry and Molecular Biology, University of Miami School of Medicine PO Box 016129, Miami, FL 33101-6129, USA

*To whom correspondence should be addressed. Tel: +1 305 243 3150; Fax: +1 305 243 3955; Email: mdeutsch{at}med.miami.edu

Received December 7, 2005. Revised January 10, 2006. Accepted January 10, 2006.

Degradation of RNA plays a central role in RNA metabolism. In recent years, our knowledge of the mechanisms of RNA degradation has increased considerably with discovery of the participating RNases and analysis of mutants affected in the various degradative pathways. Among these processes, mRNA decay and stable RNA degradation generally have been considered distinct, and also separate from RNA maturation. In this review, each of these processes is described, as it is currently understood in bacteria. The picture that emerges is that decay of mRNA and degradation of stable RNA share many common features, and that their initial steps also overlap with those of RNA maturation. Thus, bacterial cells do not contain dedicated machinery for degradation of different classes of RNA or for different processes. Rather, only the specificity of the RNase and the accessibility of the substrate determine whether or not a particular RNA will be acted upon.


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