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Nucleic Acids Research Advance Access originally published online on November 3, 2006
Nucleic Acids Research 2006 34(21):6126-6136; doi:10.1093/nar/gkl875
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Nucleic Acids Research, 2006, Vol. 34, No. 21 6126-6136
© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Molecular Biology

ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases

Jorge Lopez-Garcia, Manikandan Periyasamy, Ross S. Thomas, Mark Christian1, Maria Leao2, Parmjit Jat3, Karin B. Kindle4, David M. Heery4, Malcolm G. Parker1, Lakjaya Buluwela, Tahereh Kamalati and Simak Ali*

Department of Oncology, Imperial College London Du Cane Road, London W12 0NN, UK 1 Institute of Reproductive and Developmental Biology, Imperial College London Du Cane Road, London W12 0NN, UK 2 Ludwig Institute for Cancer Research, University College London Branch 91 Riding House Street, London W1W 7BS, UK 3 Department of Neurodegenerative Disease, Institute of Neurology, University College London Queen Square, London WC1N 3BG, UK 4 School of Pharmacy, University of Nottingham University Park, Nottingham NG7 2RD, UK

*To whom correspondence should be addressed. Tel: +44 20 8383 3789; Fax: +44 20 8383 5830; Email: simak.ali{at}imperial.ac.uk

Received August 4, 2006. Revised October 5, 2006. Accepted October 6, 2006.

The regulation of gene expression by estrogen receptor-{alpha} (ER{alpha}) requires the coordinated and temporal recruitment of diverse sets of transcriptional co-regulator complexes, which mediate nucleosome remodelling and histone modification. Using ER{alpha} as bait in a yeast two-hybrid screen, we have identified a novel ER{alpha}-interacting protein, ZNF366, which is a potent corepressor of ER{alpha} activity. The interaction between ZNF366 and ER{alpha} has been confirmed in vitro and in vivo, and is mediated by the zinc finger domains of the two proteins. Further, we show that ZNF366 acts as a corepressor by interacting with other known ER{alpha} corepressors, namely RIP140 and CtBP, to inhibit expression of estrogen-responsive genes in vivo. Together, our results indicate that ZNF366 may play an important role in regulating the expression of genes in response to estrogen.


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E. B. Dammer and M. B. Sewer
Phosphorylation of CtBP1 by cAMP-dependent Protein Kinase Modulates Induction of CYP17 by Stimulating Partnering of CtBP1 and 2
J. Biol. Chem., March 14, 2008; 283(11): 6925 - 6934.
[Abstract] [Full Text] [PDF]


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