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Nucleic Acids Research 2006 34(6):1847-1853; doi:10.1093/nar/gkl111
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Published online 4 April 2006

© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Article

NMR structure of the Aquifex aeolicus tmRNA pseudoknot PK1: new insights into the recoding event of the ribosomal trans-translation

Sylvie Nonin-Lecomte*, Brice Felden1 and Frédéric Dardel

Université Descartes Paris V - Faculté de Pharmacie, Laboratoire de Cristallographie et RMN Biologiques CNRS UMR 8015, 4, av. de l'Observatoire—75006 Paris, France 1 Université de Rennes I, UPRES JE2311 Inserm ESPRI ERI6, Biochimie Pharmaceutique, 2 avenue du Prof. Léon Bernard – 35043 Rennes, France

*To whom correspondence should be addressed. Tel: +33 1 53 73 15 74; Fax: +33 1 53 73 99 25; Email: sylvie.nonin{at}univ-paris5.fr

Received January 4, 2006. Revised January 26, 2006. Accepted March 9, 2006.

The transfer-messenger RNA (tmRNA) pseudoknot PK1 is essential for bacterial trans-translation, a ribosomal rescue mechanism. We report the solution structure of PK1 from Aquifex aeolicus, which despite an unprecedented small number of nucleotides and thus an unprecented compact size, displays a very high thermal stability. Several unusual structural features account for these properties and indicate that PK1 belongs to the class of ribosomal frameshift pseudoknots. This suggests a similarity between the mechanism of programmed ribosomal frameshifting and trans-translation.

GenBank accession no. PDB ID code: 2G1W


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