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Nucleic Acids Research 2006 34(Database Issue):D115-D118; doi:10.1093/nar/gkj093
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Nucleic Acids Research, 2006, Vol. 34, Database issue D115-D118
© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oxfordjournals.org

Article

Argonaute—a database for gene regulation by mammalian microRNAs

Priyanka Shahi1,2,3, Serguei Loukianiouk1, Andreas Bohne-Lang1, Marc Kenzelmann2, Stefan Küffer2, Sabine Maertens2, Roland Eils3, Herrmann-Josef Gröne2, Norbert Gretz1 and Benedikt Brors3,*

1Medical Research Center, University Hospital Mannheim D-68167 Mannheim, Germany 2Department of Cellular and Molecular Pathology, German Cancer Research Center D-69120 Heidelberg, Germany 3Department of Theoretical Bioinformatics, German Cancer Research Center Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany

*To whom correspondence should be addressed. Tel: +49 6221 42 3614; Fax: +49 6221 42 3620; Email: b.brors{at}dkfz.de

Received August 12, 2005. Revised October 16, 2005. Accepted October 16, 2005.

MicroRNAs (miRNAs) constitute a recently discovered class of small non-coding RNAs that regulate expression of target genes either by decreasing the stability of the target mRNA or by translational inhibition. They are involved in diverse processes, including cellular differentiation, proliferation and apoptosis. Recent evidence also suggests their importance for cancerogenesis. By far the most important model systems in cancer research are mammalian organisms. Thus, we decided to compile comprehensive information on mammalian miRNAs, their origin and regulated target genes in an exhaustive, curated database called Argonaute (http://www.ma.uni-heidelberg.de/apps/zmf/argonaute/interface). Argonaute collects latest information from both literature and other databases. In contrast to current databases on miRNAs like miRBase::Sequences, NONCODE or RNAdb, Argonaute hosts additional information on the origin of an miRNA, i.e. in which host gene it is encoded, its expression in different tissues and its known or proposed function, its potential target genes including Gene Ontology annotation, as well as miRNA families and proteins known to be involved in miRNA processing. Additionally, target genes are linked to an information retrieval system that provides comprehensive information from sequence databases and a simultaneous search of MEDLINE with all synonyms of a given gene. The web interface allows the user to get information for a single or multiple miRNAs, either selected or uploaded through a text file. Argonaute currently has information on 839 miRNAs from human, mouse and rat.


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